Stereoselective Syntheses of Tetrahydropyrans: Applications To The Synthesis Of (+)-leucascandrolide A, (+)-dactylolide And ( )-diospongin A by Kiyoun LeeStereoselective Syntheses of Tetrahydropyrans: Applications To The Synthesis Of (+)-leucascandrolide A, (+)-dactylolide And ( )-diospongin A by Kiyoun Lee

Stereoselective Syntheses of Tetrahydropyrans: Applications To The Synthesis Of (+…

byKiyoun Lee

Hardcover | March 24, 2014

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In his thesis, Kiyoun Lee describes his studies into tandem and organocatalytic oxa-conjugate addition reactions for the synthesis of complex tetrahydropyrans (THP). Readers gain insight into the new methods Lee employs for the synthesis of biologically interesting natural products including (+)-leucascandrolide A, (+)-dactylolide, and (±)diospongin A. The reactions Lee investigates are applicable to a broad range of substrates and proceed with excellent stereoselectivity. Moreover, the methodologies allow the synthesis of a wide range of THP-containing compounds. The development of reactions, such as those discussed by Lee, has the potential to impact natural product synthesis, pharmaceutical development and chemical biology.
Title:Stereoselective Syntheses of Tetrahydropyrans: Applications To The Synthesis Of (+…Format:HardcoverDimensions:184 pagesPublished:March 24, 2014Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3319044613

ISBN - 13:9783319044613

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Table of Contents

Introduction.- Significance.- General Approaches to the Synthesis of Substituted Tetrahydropyrans.- Stereoselective Synthesis of Tetrahydropyrans via Tandem and Organocatalytic Oxa-Conjugate Addition Reactions.- Introduction.- Preliminary Study.- Result and Discussion.- Synthesis of 4-Hydroxy-2,6-cis-Tetrahydropyrans via Tandem Cross-Metathesis/Thermal SN2' Reaction.