Stimulant Drugs and ADHD: Basic and Clinical Neuroscience by Mary V. SolantoStimulant Drugs and ADHD: Basic and Clinical Neuroscience by Mary V. Solanto

Stimulant Drugs and ADHD: Basic and Clinical Neuroscience

EditorMary V. Solanto, Amy F. T. Arnsten, F. Xavier Castellanos

Hardcover | November 15, 2000

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Stimulant drugs are widely used in the treatment of ADHD in children and adults. Hundreds of studies over the past 60 years have demonstrated their effectiveness in improving attention span, increasing impulse control, and reducing hyperactivity and restlessness. Despite widespread interest inthese compounds, however, their mechanisms of action in the central nervous system have remained poorly understood. Recent advances in the basic and clinical neurosciences now afford the possibility of elucidating these mechanisms. The current volume is the first to bring this expanding knowledge tobear on the central question of why and how stimulants exert their therapeutic effects. The result is a careful, comprehensive, and insightful integration of material by well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research.Part I presents a comprehensive description of the clinical features of ADHD and the clinical response to stimulants. Part II details the cortical and subcortical neuroanatomy and functional neurophysiology of dopamine and norepinephrine systems with respect to the regulation of attention, arousal,activity, and impulse control and the effects of stimulants on these systems. Part III is devoted to clinical research, including recent studies of neuroimaging, genetics, pharmacodynamic and pharmacokinetic properties of stimulants, effects on cognitive functions, neurophysiological effects inhumans with and without ADHD and in non-human primates, and comparison of stimulants and non-stimulants in the treatment of ADHD. Part IV is a masterful synthesis that presents alternative models of stimulant drug action and generates key hypotheses for continued research. The volume will be of keeninterest to researchers and clinicians in psychiatry, psychology, and neurology, neuroscientists studying stimulants, and those pursuing development of new drugs to treat ADHD.
Mary V. Solanto is at The Mount Sinai Medical Center. Amy F. T. Arnsten is at Yale University School of Medicine, NewHaven.
Title:Stimulant Drugs and ADHD: Basic and Clinical NeuroscienceFormat:HardcoverPublished:November 15, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195133714

ISBN - 13:9780195133714

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Table of Contents

Part I: Phenomenology1. Mary V. Solanto: Attention-Deficit/Hyperactivity Disorder: Clinical Features2. Lawrence L. Greenhill: Clinical Effects of Stimulant Medication in ADHDPart II: Basic NeuroscienceAmy F.T. Arnsten: Introduction3. David A. Lewis: The Catecholamine Innervation of Primate Cerebral Cortex4. Jane R. Taylor and J. David Jentsch: Stimulant Effects on Striatal and Cortical Dopamine Systems Involved in Reward-Related Behavior and Impulsivity5. Anthony A. Grace: Psychostimulant Actions on Dopamine and Limbic System Function: Relevance to the Pathophysiology and Treatment of ADHD6. Craig W. Berridge: Arousal- and Attention-Related Actions of the Locus Coeruleus-Noradrenergic System: Potential Target in the Therapeutic Actions of Amphetamine-Like Stimulants7. Amy F.T. Arnsten: Dopaminergic and Noradrenergic Influences on Cognitive Functions Mediated by Prefrontal Cortex8. Sherry A. Ferguson: A Review of Rodent Models of ADHD9. Terje Sagvolden: The Spontaneously Hypertensive Rat as a Model of ADHDPart III: Clinical NeuroscienceMary V. Solanto: Introduction10. F. Xavier Castellanos: Neuroimaging Studies of ADHD11. James Swanson and Nora Volkow: Pharmacokinetic and Pharmacodynamic Properties of methylphenidate in Humans12. Colin B. Denney and Mark D. Rapport: The Cognitive Pharmacology of Stimulants in Children with ADHD13. Mitul A. Mehta, Barbara J. Sahakian, and Trevor W. Robbins: Comparative Psychopharmacology of Methylphenidate and Related Drugs in Human Volunteers, Patients with ADHD, and Experimental Animals14. Steven R. Pliszka: Comparing the Effects of Stimulant and Non-Stimulant Agents on Catecholamine Function: Implications fot Theories of ADHDPart IV: Integration15. Mary V. Solanto, Amy F.T. Arnsten, and F. Xavier Castellanos: The Neuroscience of Stimulant Drug Action in ADHDAppendix:. Charles Bradley: The Behavior of Children Receiving BenzedrineIndex

Editorial Reviews

"This slender volume is an excellent collection of reviews on ADHD in the context of modern psychopharmacology and neuroscience....The quality of all the chapters is consistently of a very high standard, each text a gem on its own. They are concisely written and densely packed with relevantinformation. The materials are accessible, despite being technical in nature...a superb set of essays....Overall, this is--and I believe will remain for some time--a benchmark publication, relevant to any clinician who prescribes ADHD psychopharmacological treatment, and to investigators in ADHDresearch from medical or neuroscience backgrounds alike."--Journal of Child Psychology and Psychiatry