Stroke Genetics

Hardcover | May 1, 2003

EditorHugh S. Markus

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Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke. Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

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From the Publisher

Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing st...

Hugh Markus is a Professor of Neurology, St George's Hospital Medical School, London, UK.

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Format:HardcoverDimensions:358 pages, 9.45 × 6.46 × 0.94 inPublished:May 1, 2003Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198515863

ISBN - 13:9780198515869

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Table of Contents

Preface1. Markus: An introduction to stroke2. Catto and Carter: Genetic principles and techniques3. Meschia and Brown: Genetic epidemiology of stroke4. Sagnella: Genetics of conventional stroke risk factors5. Rubattu, Gigante, Stanzione and Volpe: Animal models of stroke: implications for genetic studies of human stroke6. Dichgans: Monogenic causes of ischaemic stroke7. Hassan and Markus: Polygenic ischaemic stroke including new genetic and statistical approaches8. Jerrard-Dunne, Hassan and Markus: Investigating the genetics of polygenic ischaemic stroke using intermediate phenotypes9. Haan: Genetics of intracerebral haemorrhage10. Schievink: Genetics of subarachnoid haemorrhage and intracranial aneurysms11. Labauge: Familial cerebral arteriovenous malformations12. Kirkham and Prengler: The genetics of paediatric stroke13. Markus: Investigating a patient with stroke for genetic causes14. Markus: Useful web sites for stroke genetics