Stroke Genomics: Methods and Reviews by Simon J. ReadStroke Genomics: Methods and Reviews by Simon J. Read

Stroke Genomics: Methods and Reviews

EditorSimon J. Read

Paperback | November 10, 2010

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Leading experts explore the pragmatic application of the tools of genomic and molecular biology research to the treatment of stroke. Providing the reader with cutting-edge reviews of clinical and preclinical genomics, the authors relate changes in gene expression to physiological endpoints-such as functional imaging paradigms-to produce a more holistic approach in which molecular biology goes hand-in-hand with stroke pathophysiology. Topics of special interest include stem cell transplantation, gene therapy, clinical gene/gene interaction studies, and cytokine drug discovery. Readily reproducible techniques are provided, along with ancillary methods (imaging, animal models, human genetic study design, and transgenic animal production) that can be effectively applied to gene discovery. The book shows how to successfully design, execute, and interpret preclinical and clinical molecular biological studies of stroke, work that will greatly advance its understanding, as well as rapid development of the next generation of stroke therapeutics.
Title:Stroke Genomics: Methods and ReviewsFormat:PaperbackDimensions:361 pagesPublished:November 10, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617375004

ISBN - 13:9781617375002

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Table of Contents

Part I. IntroductionIntroduction to Stroke GenomicsSimon J. Read and Frank C. BaronePart II. Preclinical Models and Gene ManipulationChoice, Methodology, and Characterization of Focal Ischemic Stroke Models: The Search for Clinical RelevanceDavid VirleyMutant Animal Models of Stroke and Gene Expression: The Stroke-Prone Spontaneously Hypertensive RatHilary V. O. Carswell, Martin W. McBride, Delyth Graham, Anna F. Dominiczak, and I. Mhairi MacraeGene Therapy in Neurological DiseaseMidori A. Yenari and Robert M. SapolskyStem Cell Transplantation After Middle Cerebral Artery OcclusionPaul Stroemer and Helen HodgesEndogenous Brain Protection: Models, Gene Expression, and MechanismsFrank C. BaroneProduction of Transgenic and Mutant Mouse ModelsAlex J. Harper3-Nitropropionic Acid Model of Metabolic Stress: Assessment by Magnetic Resonance ImagingToby John RobertsPart III. Clinical ParadigmsPracticalities of Genetic Studies in Human StrokeAhamad Hassan and Hugh S. MarkusEvaluation of the Interactions of Common Genetic Mutations in StrokeZoltán SzolnokiPart IV. Assessing Differential ExpressionTechnologies of Disease-Related Gene Discovery Using Preclinical Models of StrokeXinkang WangQuantitative Analysis of Gene Transcription in Stroke Models Using Real-Time RT-PCRDavid C. Harrison and Brian C. BondEffective Analysis of Genomic DataPaul R. Nelson, Andrew B. Goulter, and Richard J. DavisBioinformatic Approaches to Assigning Protein Function From Novel Sequence DataDavid Michalovich and Richard FaganPragmatic Target Discovery From Novel Gene to Functionally Defined Drug Target: The Interleukin-1 StoryStuart McRae AllanIndexf

Editorial Reviews

From the reviews:"The protocols presented in Stroke Genomics: Methods and Reviews will greatly benefit scientists interested in the molecular biology as well as the genetic and genomic basis of strokes." - Journal of Chemical Neuroanatomy"...very interesting and informative...an attractive and interesting overview of the different aspects of the current stroke research...can be recommended as a source of useful and up-to-date practical and theoretical information on stroke genetics and on stroke associated gene expression." - European Neurology"This book gives the opportunity for experts in the field to explore the practical and experimental applications of genomic and molecular biology research to the treatment of stroke. . The book also indicates detailed methods for studying the molecular biology of stroke. . It can be recommended if one is interested in the basic scientific background that underlies central nervous system pathology . ." (J. V. Byrne, Neuroradiology, Vol. 47, 2005)