Structural and Functional Organization of the Synapse

Hardcover | July 7, 2008

EditorJohannes W. Hell, Michael D. Ehlers

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This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse's functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structural level and can thus be considered firmly established. It's an important text for neuroscientists and disease-oriented clinicians in neurology.

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This new Springer volume, which comes complete with a free DVD, is a comprehensive and detailed overview of the synapse with emphasis on the glutamatergic synapse. Most chapters relate the synapse's functional aspects to its molecular mechanisms. This approach shows which mechanisms are characterized on both the functional and structur...

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Synapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement. This bo...

Format:HardcoverDimensions:819 pages, 9.25 × 6.1 × 0.27 inPublished:July 7, 2008Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387772316

ISBN - 13:9780387772318

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Table of Contents

Introduction.- Transport and Storage of neurotransmitters.- The neurotransmitter release machinery.- Endocytic retrieval of synaptic vesicles.- Linking the release machinery to neuronal excitation: SNARE binding to presynaptic Ca channels.- Attaching the release machinery with the synaptic cleft matrix: Ca channel interaction with laminin.- Connect the presynaptic and postsynaptic site: neurexins, neuroligins, SynCAMs, and their intracellular binding partners.- Structural and functional aspects of glutamate binding to the AMPA receptor.- The role of Stargazin and PSD95 in AMPA receptor accumulation at the postsynaptic site.- Cell biology and biochemistry of the NMDA R.- Physiology and Biophysics of Glutamate receptors.- The regulators: postsynaptic targeting of protein kinases and phosphatases.- The postsynaptic scaffolding proteins.- The postsynaptic cytoskeleton.- Synpatic plasticity: LTP and LTD.- Development of the Synapse.- Metabotropic Glutamate receptors.- The GABAergic synapse.- The glycinergic synapse.- Postsynaptic ion channels (SK K channels, which regulate NMDA receptor activity, Ca channels.- Stroke: Excitotoxicity by glutamate.- Synaptic contributions to epilepsy.- Huntington's and related polyglutamine expansion diseases and their effect on the synapse.- Dysregulation of synaptic function in Alzheimer's disease.- The role of synaptic alterations in chronic pain.- Autism from a synaptic perspective.- Anxiety disorders.- Depression.- Schizophrenia.