Structural Biology Using Electrons and X-rays: An Introduction for Biologists

Paperback | January 19, 2011

byMichael F MoodyEditorMichael F Moody

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Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance NMR , which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen's symmetry i.e., crystals, helices, polyhedral viruses and asymmetrical particles . This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance NMR . It is also suitable for readers without a background in physical chemistry or mathematics. *Emphasis on common principles underlying all diffraction-based methods *Thorough grounding in theory requires understanding of only simple algebra *Visual representations and explanations of challenging content *Mathematical detail offered in short-course form to parallel the text

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From the Publisher

Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five par...

From the Jacket

This book, suitable for advanced undergraduates or graduate students, provides an accessible introduction to the two major diffraction-based techniques of structural biology. While concentrating on electron cryo-microscopy with image analysis, it also includes X-ray crystallography in a coherent survey of fundamental principles. Starti...

Format:PaperbackDimensions:450 pages, 9.25 × 7.5 × 0.68 inPublished:January 19, 2011Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123705819

ISBN - 13:9780123705815

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Extra Content

Table of Contents

Part I: Fourier Transforms

1. Overview

2. Correlations & Convolutions

3. Fourier Fundamentals

4. Digital Fourier Transforms

5. Filters

6. Two-Dimensional FTs

Part II: Optics

7. Microscopy with Rays

8. Waves

9. Wave Imaging

Part III: Further Mathematical Methods/General Aspects

10. Symmetry

11. Statistics & Matrices

12. The Third Dimension

Part IV: Image Analysis/Structure Determination

13. Special Symmetries

14. Crystalline Sheets

15. Helices

16. Icosahedral Particles

17. Unsymmetrical ("Single") Particles

18. Distortion Correction

19. FT Mathematics

20. Elementary Matrices