Structure and Dynamics of Biomolecules: Neutron and Synchrotron Radiation for Condensed Matter…

Paperback | February 10, 2000

byEric Fanchon, Erik Geissler, Jean-Louis Hodeau

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HERCULES is a course on the underlying principles and methods of neutron and synchrotron radiation techniques used in scientific research, constructed around laboratory practicals, tutorials and lectures and designed for biologists, chemists, geologists and physicists. This volume, the fourthin the HERCULES series, is the basis of the lecture course describing the theory and practice of techniques using either thermal neutrons or X- rays from a synchrotron source applied to the modern problems of biology. The themes treated are the crystallographic determination of protein structure,protein dynamics and partially ordered systems. A fourth section on more specialized topics includes spectroscopic techniques, X-ray microscopy, neutron spin polarization contrast methods and investigations of more complex molecules. Each chapter describes a different aspect of the subject, and thecontributors are international authorities in their field. The book will be of use not only to beginners, but also, owing to the breadth of its scope, for experienced practitioners.

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HERCULES is a course on the underlying principles and methods of neutron and synchrotron radiation techniques used in scientific research, constructed around laboratory practicals, tutorials and lectures and designed for biologists, chemists, geologists and physicists. This volume, the fourthin the HERCULES series, is the basis of the...

Eric Fanchon is at Institut de Biologie Structurale Jean-Pierre Ebel, Grenoble. Erik Geissler is at the Laboratoire de Spectrometrie Physique. Jean-Louis Hodeau is at the Laboratoire de Cristallographie, CNRS.
Format:PaperbackPublished:February 10, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198504527

ISBN - 13:9780198504528

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Table of Contents

ForewordIntroductionChallenges in structural molecular biology: genomics in three dimensionsData collection and reduction methodsExperimental phase determination of structure factors phases in biocrystallographyElectron density - calculation, modification and interpretationNeutron crystallography of biological moleculesReactions in crystals and time-resolved crystallographyLocal structure of metalloproteins at atomic resolution by XAFSMolecular dynamicsInelastic and Quasielastic neutron scattering: complementarity with biomolecular simulationDiffuse X-ray scattering from molecular crystalsSmall-angle X-ray scattering by solutions of biological macromoleculesSmall angle neutron scatteringStructure, dynamic and function of the proton pump bacteriorhodopsinFibre and muscle diffractionBiological spectroscopy using low energy (VUV/UV) synchrotron radiationX-ray microscopyCrystallography of viruses and very large macromoleculesThe quest for high resolution phasing for large macromolecular assemblies exhibiting severe non-isomorphism, extreme beam sensitivity and no internal symmetryNuclear spin contrast variation studies on macromolecular complexes