Suicide Gene Therapy: Methods and Reviews by Caroline J. SpringerSuicide Gene Therapy: Methods and Reviews by Caroline J. Springer

Suicide Gene Therapy: Methods and Reviews

EditorCaroline J. Springer

Paperback | November 9, 2010

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The first comprehensive review of both the theory and practice of suicide gene therapy. The authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, immunological implications, and its clinical impact. They also describe all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results.
Title:Suicide Gene Therapy: Methods and ReviewsFormat:PaperbackDimensions:560 pagesPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372838

ISBN - 13:9781617372834

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Table of Contents

Introduction to the Background, Principles, and State of the Art in Suicide Gene TherapyIon Niculescu-Duvaz and Caroline J. SpringerIntroduction to Vectors for Suicide Gene TherapyCaroline J. SpringerConstruction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in HumansKenneth Brooks Low, Martina Ittensohn, Xiang Luo, Li-Mou Zheng, Ivan King, John M. Pawelek, and David BermudesNonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral VectorsMasato Yamamoto and David T. CurielReplication-Selective Oncolytic AdenovirusesGunnel Halldén, Stephen H. Thorne, Jingping Yang, and David H. KirnRetroviral Vectors for Suicide Gene TherapyColin PorterNonviral LiposomesAndrew D. MillerPeptide- and Polymer-Based Gene Delivery VehiclesRichard Brokx and Jean GariépyDesign of Prodrugs for Suicide Gene TherapyDan Niculescu-Duvaz, Ion Niculescu-Duvaz, and Caroline J. SpringerCytochrome P450-Based Gene Therapies for CancerE. Antonio Chiocca and David J. WaxmanTumor Sensitization to Purine Analogs by E. coli PNPKimberly V. Curlee, William B. Parker, and Eric J. SorscherEnzyme-Prodrug Systems: Carboxylesterase/CPT-11Mary K. Danks and Philip M. PotterEnzyme-Prodrug Systems: Thymidine Phosphorylase/5'-Deoxy-5-FluorouridineAlexandre Evrard, Joseph Ciccolini, Pierre Cuq, and Jean-Paul CanoMethods to Improve Efficacy in Suicide Gene Therapy Approaches: Targeting Prodrug-Activating Enzymes Carboxypeptidase G2 and Nitroreductase to Different Subcellular CompartmentsSilke Schepelmann, Robert Spooner, Frank Friedlos, and Richard MaraisExtracellular b-Glucuronidase for Gene-Directed Enzyme-Prodrug TherapySabine BrüsselbachEnhancement of Suicide Gene Prodrug Activation by Random MutagenesisJean-Emmanuel Kurtz and Margaret E. BlackCombination Suicide Gene TherapyWolfgang Uckert, Brian Salmons, Christian Beltinger, Walter H. Günzburg, and Thomas KammertönsImmune Response to Suicide Gene TherapyShigeki Kuriyama, Hirohisa Tsujinoue, and Hitoshi YoshijiTargeting Cancer With Gene Therapy Using Hypoxia as a StimulusGabi U. Dachs, Olga Greco, and Gillian M. TozerRadiation-Activated Antitumor VectorsSimon D. Scott and Brian MarplesIn Vitro and In Vivo Models for the Evaluation of GDEPT: Quantifying Bystander Killing in Cell Cultures and TumorsWilliam R. Wilson, Susan M. Pullen, Alison Hogg, Stephen M. Hobbs, Frederik B. Pruijn, and Kevin O. HicksSuicide Gene Therapy in Liver TumorsLong R. Jiao, Roman Havlik, Joanna Nicholls, Steen Lindkaer Jensen, and Nagy A. HabibClinical Trials With GDEPT: Cytosine Deaminase and 5-FluorocytosineNicola L. Brown and Nicholas R. LemoineThe Nitroreductase/CB1954 Enzyme-Prodrug SystemNicola K. Green, David J. Kerr, Vivien Mautner, Peter A. Harris, and Peter F. SearleSide Effects of Suicide Gene TherapyMarjolijn M. van der Eb, Bertie de Leeuw, Alex J. van der Eb, and Rob C. HoebenAntibody-Directed Enzyme-Prodrug TherapyR. Barbara Pedley, Surinder K. Sharma, Robert E. Hawkins, and Kerry A. ChesterBioreductive Prodrugs for Cancer TherapyBeatrice Seddon, Lloyd R. Kelland, and Paul WorkmanIndex

Editorial Reviews

"This is a good book for those working in the area of suicide gene therapy that can serve both as a reference to senior investigators as well as a primer to new lab members and researchers outside the field who are trying to get a flavor of the state of the field."-Doody's Health Sciences Book Review Journal"...an extensive review of the theoretical background of suicide gene therapy that covers all major aspects..." - ChemBioChem"Authoritative and up-to-date...provides the experimental means to advance its future development and therapeutic applications." - Anticancer Research