Synthetic Peptides: A Users Guide

Paperback | March 15, 2002

EditorGregory Grant

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The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are often unfamiliar with not only the syntheticchemistry but also with important and useful aspects of design, analysis, handling, and applications. This volume is the second edition of a volume that was first published 10 years ago. It is written by experts in the field who provide detailed descriptions as well as practical advice for producingand using synthetic peptides. The various chapters cover peptide design considerations, the synthetic chemistry, the evaluation of the synthetic product, and the modern applications of synthetic peptides. This includes the basic principles of peptide structure, analysis and chain assembly as well asthe latest in selective disulfide bond formation, new strategies for the production of large peptides, and sequencing peptides by mass spectrometry. This book was designed with the intent of providing useful information both for the novices to the field as well as more seasoned practitioners. Itscontents will help prevent problems commonly encountered and allow scientists to optimize their use of synthetic peptides.

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The first synthetic peptides were produced a century ago. In the ensuing period, they have developed as valuable research tools that are readily available to all researchers. However, since most researchers do not make their own peptides, they are often unfamiliar with not only the syntheticchemistry but also with important and useful ...

Gregory Grant is at Washington University School of Medicine.

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Format:PaperbackDimensions:400 pages, 6.1 × 9.29 × 0.98 inPublished:March 15, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195132610

ISBN - 13:9780195132618

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Table of Contents

Contributors1. Gregory A. Grant: Synthetic Peptides: Beginning the Twenty-first Century2. Michael L. Moore and Gregory A. Grant: Peptide Design Considerations3. Gregg B. Fields, Janelle L. Lauer-Fields, Rong-qiang Liu, and George Barany: Principles and Practice of Solid-Phase Peptide Synthesis4. Gregory A. Grant: Evaluation of the Synthetic Product5. Victor J. Hruby and Terry O. Matsunaga: Applications of Synthetic PeptidesIndex

Editorial Reviews

"[A] valuable resource for anyone involved in peptide research. This book would also serve as a good reference book for a course devoted to peptide chemistry."--Polymer News