Systems Biology: Volume I: Genomics

Hardcover | September 20, 2006

EditorIsidore Rigoutsos, Gregory Stephanopoulos

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The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach.The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number oftraditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for acomprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining togenomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.

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The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach.The processing and interpretation of these ne...

Isidore Rigoutsos is at MIT. Gregory Stephanopoulos is at MIT.

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Format:HardcoverDimensions:336 pages, 6.3 × 9.29 × 0.79 inPublished:September 20, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195300815

ISBN - 13:9780195300819

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Table of Contents

1. Stanley L. Miller and H. James Cleaves: Prebiotic Chemistry on the Primitive Earth 32. Antonio Lazcano: Prebiotic Evolution and the Origin of Life: Is a System-Level Understanding Feasible? 573. Granger Sutton and Ian Dew: Shotgun Fragment Assembly 794. John Besemer and Mark Borodovsky: Gene Finding 1185. Temple F. Smith: Local Sequence Similarities 1546. Michael Y. Galperin and Eugene V. Koonin: Complete Prokaryotic Genomes: Reading and Comprehension 1667. Jeffrey Skolnick and Yang Zhang: Protein Structure Prediction 1878. Gary D. Stormo: DNA-Protein Interactions 2199. Michael Syvanen: Some Computational Problems Associated with Horizontal Gene Transfer 24810. Noncoding RNA and RNA Regulatory Networks in the Systems Biology of Animals 269John S. Mattick: Index 303