Systems Biology: Volume II: Networks, Models, and Applications

Hardcover | September 14, 2006

EditorIsidore Rigoutsos, Gregory Stephanopoulos

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The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach.The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number oftraditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for acomprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining togenomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.

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The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach.The processing and interpretation of these ne...

Isidore Rigoutsos is a Manager at Bioinformatics Group, IBM TJ Watson Research Center. Gregory Stephanopoulos is a Professor of Chemical Engineering and Biotechnology at MIT.

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Format:HardcoverDimensions:366 pages, 6.3 × 9.41 × 0.79 inPublished:September 14, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195300807

ISBN - 13:9780195300802

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Table of Contents

1. Cristian I. Ruse and John R. Yates III: Mass Spectrometry in Systems Biology 32. C. A. Floudas and H. K. Fung: Mathematical Modeling and Optimization Methods for De Novo Protein Design 423. William C. Swope, Jed W. Pitera, and Robert S. Germain: Molecular Simulation and Systems Biology 674. G. A. Held, Gustavo Stolovitzky, and Yuhai Tu: Global Gene Expression Assays: Quantitative Noise Analysis 1035. Jason A. Papin, Erwin P. Gianchandani, and Shankar Subramaniam: Mapping the Genotype-Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown 1376. Dimitrios Mastellos and John D. Lambris: Integrating Innate Immunity into a Global "Systems" Context: The Complement Paradigm Shift 1697. Sang Yup Lee, Dong-Yup Lee, Tae Yong Kim, Byung Hun Kim, and Sang Jun Lee: Systems Biotechnology: Combined in Silico and Omics Analyses for the Improvement of Microorganisms for Industrial Applications 1938. Markus J. Herrgard and Bernhard O. Palsson: Genome-Scale Models of Metabolic and Regulatory Networks 2329. Raimond L. Winslow, Joseph. L. Greenstein, and Patrick A. Helm: Biophysical Models of the Cardiovascular System 26510. Andrew M. Thomson, Paul Robson, Huck Hui Ng, Hasan H. Otu, and Bing Lim: Embryonic Stem Cells as a Module for Systems Biology 297Index 319