T-box Genes In Development And Disease by Manfred Frasch

T-box Genes In Development And Disease

byManfred Frasch

Hardcover | January 5, 2017

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T-box Genes in Development and Diseaselooks at the genes encoding the T-box family of transcription factors function as key regulators of many important decision processes during embryonic and tissue development. The importance of these genes is further underlined by the fact that most members of this gene family have been conserved during evolution from worms to humans. This book brings together the current information on conserved aspects with the evolutionary innovations of the functions of these genes during developmental regulation in various animal species and then discusses their important roles in human disease.



  • Brings together current knowledge from a wide variety of animal species and humans
  • Presents commentary from authoritative experts, and includes many prominent scientists and their research
  • Illuminates the connections between developmental biology, evolution, and human disease
  • Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

About The Author

Manfred Frasch is chair of the Division of Developmental Biology in the Department of Biology at Friedrich-Alexander-University of Erlangen-Nürnberg in Germany. From 1991 to 2006 he was on the faculty of Mount Sinai School of Medicine, New York, where he retains an Adjunct Professor status. Prior to that, Frasch received his Ph.D. degr...

Details & Specs

Title:T-box Genes In Development And DiseaseFormat:HardcoverDimensions:444 pages, 9.41 × 7.24 × 0.98 inPublished:January 5, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:012801380X

ISBN - 13:9780128013809

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Table of Contents

  1. Evolution and Classification of the T-Box Transcription Factor Family
  2. A. Sebé-Pedrós and I. Ruiz-Trillo

  3. The Remarkably Diverse Family of T-Box Factors inCaenorhabditis elegans

    P.G. Okkema

  4. T-Box Genes and Developmental Gene Regulatory Networks in Ascidians
  5. A. Di Gregorio

  6. Eomesodermin At Dawn of Cell Fate Decisions During Early Embryogenesis
  7. S. Probst and S.J. Arnold

  8. Cooperation Between T-Box Factors Regulates the Continuous Segregation of Germ Layers During Vertebrate Embryogenesis
  9. G.E. Gentsch, R.S. Monteiro and J.C. Smith

  10. T-Box Genes inDrosophilaMesoderm Development
  11. I. Reim, M. Frasch and C. Schaub

  12. TBX5: A Key Regulator of Heart Development
  13. J.D. Steimle and I.P. Moskowitz

  14. Tbx1: Transcriptional and Developmental Functions
  15. A. Baldini, F.G. Fulcoli and E. Illingworth

  16. T-Box Genes in the Kidney and Urinary Tract
  17. A. Kispert

  18. Control of Neuronal Development by T-Box Genes in the Brain
  19. A.B. Mihalas and R.F. Hevner

  20. T-Box Genes inDrosophilaLimb Development
  21. G.O. Pflugfelder, F. Eichinger and J. Shen

  22. The Roles of T-Box Genes in Vertebrate Limb Development
  23. C.J. Sheeba and M.P.O. Logan

  24. T-Box Genes in Human Development and Disease T.K. Ghosh, J.D. Brook and A. Wilsdon