T Cell Subsets: Cellular Selection, Commitment And Identity

Other | June 1, 2004

byAlt, Frederick W., Frederick W. Alt

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This first thematic issue, of theAdvances in Immunologyseries, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.

T Cell Subsetsis a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers

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This first thematic issue, of theAdvances in Immunologyseries, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a funda...

Format:OtherDimensions:304 pages, 1 × 1 × 1 inPublished:June 1, 2004Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080551955

ISBN - 13:9780080551951

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Table of Contents

Early Lymphoid Progenitor Subsets - Lineage Commitment and Developmental Plasticity
The CD4/CD8 Lineage Choice: New Insights
Analysis of the CD4/CD8 Lineage Decision
Development and Function of T Helper 1 Cells
Th2 cells: Orchestrating Barrier Immunity
Memory T. Cells -Generation, Maintenance, and Function
An Integrated Model of Immunoregulation