Targets for Cancer Chemotherapy: Transcription Factors And Other Nuclear Proteins by Nicholas B. La ThangueTargets for Cancer Chemotherapy: Transcription Factors And Other Nuclear Proteins by Nicholas B. La Thangue

Targets for Cancer Chemotherapy: Transcription Factors And Other Nuclear Proteins

byNicholas B. La Thangue

Paperback | November 19, 2010

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In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.
Title:Targets for Cancer Chemotherapy: Transcription Factors And Other Nuclear ProteinsFormat:PaperbackDimensions:352 pages, 22.9 × 15.2 × 0.01 inPublished:November 19, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617372633

ISBN - 13:9781617372636

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Table of Contents

Cancer Chemotherapy Based on E2F and the Retinoblastoma PathwayWilliam G. Kaelin, JrMyc Oncoproteins as Targets for Therapeutic Intervention in TumorigenesisBernd Berwanger and Martin EilersThe AP-1 Family of Transcription Factors: Structure, Regulation, and Functional Analysis in MiceMarina Schorpp-Kistner, Peter Herrlich, and Peter AngelHypoxia-Induced Factor-1 as a Target for Anticancer TherapyShoumo BhattacharyaNuclear b-Catenin Signaling as a Target for Anticancer Drug DevelopmentEun Joo Chung, Paolo Bonvini, Ho Jung Oh, Len Neckers, and Jane TrepelHistone Acetyltransferases as Potential Targets for Cancer TherapiesStuart Thomson and Louis C. MahadevanHistone DeacetylasesManfred JungCyclin-Dependent Kinases and Their Small-Molecule Inhibitors in Cancer TherapyR. Nagaraja Rao and Bharvin K. R. PatelMitogen-Activated Protein Kinase Cascades as Therapeutic Targets in CancerAntonio Chiloeches and Richard MaraisMdm2 and ARFAndrea Klotzbücher and Michael H. G. KubbutatThe Breast Cancer Susceptibility Genes, BRCA1 and BRCA2Anastasia Gabriel and Alan AshworthHuman Papillomavirus: Targets for Therapeutic InterventionDavid Pim, Miranda Thomas, and Lawrence BanksApoptin as an Anticancer TherapyMathieu H. M. NotebornE2F and Cancer ChemotherapyDebabrata Banerjee and Joseph R. BertinoHypoxic Signaling Pathways as Targets for Anticancer TherapyHeidi M. Sowter and Adrian L. HarrisAndrogen Receptor and Estrogen ReceptorsH. M. Oosterkamp and R. Bernards

Editorial Reviews

'This book will be of interest to drug development professionals and oncology researchers. Specific chapters make good reviews for clinicians interested in emerging therapies and may also be useful for students." - Today's Life Science"The book is included in the successful series of publications "Cancer Drug Discovery and Development" form Humana Press. It will be of interest both to clinicians and to laboratory cancer researchers, as well as to people who are interested in recent achievements in molecular oncology, which gives new hope for better treatment of caner patients." - Neoplasma