Telomeres and Telomerase in Cancer by Keiko HiyamaTelomeres and Telomerase in Cancer by Keiko Hiyama

Telomeres and Telomerase in Cancer

EditorKeiko Hiyama

Paperback | November 19, 2010

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Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in "cancer stem cells" has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

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Title:Telomeres and Telomerase in CancerFormat:PaperbackDimensions:392 pages, 9.25 × 6.1 × 0 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617378887

ISBN - 13:9781617378881

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Table of Contents

PrefaceContributorsPart I. Basic background1 Telomeres and Telomerase in Human Keiko Hiyama, Eiso Hiyama, and Jerry W. Shay2 Telomere Binding Proteins in HumanNadya Dimitrova3 Regulation of Telomerase through Transcriptional and Post-Translational MechanismsAmy N. Depcrynski, Patrick C. Sachs, Lynne W. Elmore, and Shawn E. Holt4 Telomere Dysfunction and the DNA Damage ResponseMalissa C. Diehl, Lynne W. Elmore, Shawn E. Holt5 Alternative Lengthening of Telomeres (ALT) in Human CellsHilda A. Pickett and Roger R. Reddel6 Mouse model: Telomeres and Telomerase in Stem Cell and CancerXin Huang, Zhenyu JuPart II Telomeres and telomerase in human cancers7 Role of Telomeres and Telomerase in CancerKeiko Hiyama, Eiso Hiyama, Keiji Tanimoto, Masahiko Nishiyama8 Diagnostic Value 1: Solid TumorsEiso Hiyama and Keiko Hiyama9 Diagnostic Value 2: Hematopoietic MalignanciesJunko H. Ohyashiki and Kazuma Ohyashiki10 Therapeutic Targets and Drugs 1: Telomerase and Telomerase InhibitorsBrittney-Shea Herbert and Erin M. Goldblatt11 Therapeutic Targets and Drugs 2: G-quadruplex and G-quadruplex InhibitorsChandanamali Punchihewa and Danzhou Yang12 Therapeutic Targets and Drugs 3: Tankyrase 1, Telomere Binding Proteins, and InhibitorsHiroyuki Seimiya and Takashi Tsuruo13 Therapeutic Targets and Drugs 4: Telomerase-specific Gene and Vector-based Therapies for Human CancerToshiyoshi Fujiwara, Yasuo Urata, and Noriaki TanakaPart III Experimental protocols14 Protocol 1: Telomerase Activity and Telomerase Expression Eiso Hiyama15 Protocol 2: Importance and Methods of Telomere G-tail Length Quantification Akira Shimamoto, Eriko Aoki, Angie M Sera, Hidetoshi Tahara 16 Protocol 3: Detection of Alternative Lengthening of Telomeres (ALT)Wei-Qin Jiang, Jeremy D. Henson, Axel A. Neumann, and Roger R. ReddelIndex