Textbook of Cancer Epidemiology

Hardcover | January 25, 2008

EditorHans-Olov Adami, David Hunter, Dimitrios Trichopoulos

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This superb text gives a concise, systematic account of what is currently known about the epidemiology and primary prevention for most forms of human cancer. Part 1 provides an introduction to basic concepts in epidemiology, a description of the global burden of cancer, definitions andcharacterizations of the various measures used, and approaches used to reveal genetic determinants of cancer risk and integrate biologic markers in the epidemiogic research process. Part 2 contains chapters of uniform structure on over 20 types of cancer, providing clinical and pathologicaloutlines, descriptive epidemiology, and a comprehensive account of risk factors and their etiological importance. Specific sections address somatic and germ cell mutations that play a role in the occurrence of particular forms of cancer.

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This superb text gives a concise, systematic account of what is currently known about the epidemiology and primary prevention for most forms of human cancer. Part 1 provides an introduction to basic concepts in epidemiology, a description of the global burden of cancer, definitions andcharacterizations of the various measures used, and...

Hans-Olov Adami is a Professor of Cancer Epidemiology and Chairman of the Department of Medical Epidemiology at the Karolinska Institute in Sweden. David Hunter is a Professor of Epidemiology and Nutrition at the Harvard School of Public Health. Dimitrios Trichopoulos is a Vincent L. Gregory Professor of Cancer Prevention and Professo...
Format:HardcoverDimensions:720 pages, 10 × 7.2 × 1.6 inPublished:January 25, 2008Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195311175

ISBN - 13:9780195311174

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Table of Contents

PART I: BACKGROUND1. Brian MacMahon: Accomplishments in Cancer EpidemiologyReproductionAlcoholIatrogenic ExposureDietConclusionReferences2. Pagona Lagiou, Johanna Adami and Dimitrios Trichopoulos: Burden of CancerMeasures of Disease burdenIncidenceAge-standardizationCumulative IncidencePrevalenceSurvivalMortalityYears of Life LostDisability-adjusted Life YearsCancer in the WorldCancer and other Causes of DeathCancer Burden by SiteCancer Burden by CauseTrends in Mortality in the USGeographic Variability by siteOverall Cancer SurvivalConclusionReferences3. Jeffrey Ecsedy and David Hunter: The Origin of CancerDefining CancerCancer ProgressionMetastasisCellular Origin of CancerClinical Behavior of CancerA Molecular Approach to Understanding CancerCancer GenesGenetic CarcinogenesisExogenous MutagenesisEpigenetic Mechanisms of Gene SilencingThe Cell Cycle and CheckpointsGenomic Instability DisordersThe p53 and Retinoblastoma PathwaysGrowth-Regulatory Signaling PathwaysProgrammed Cell Death (Apoptosis)Unlimited Replicative Potential of CancerExtrinsic factors influence cancer progressionThe Extracellular MatrixAngiogenesisEvasion of Immune-Mediated EradicationConclusionReferences4. Christopher Haiman and David Hunter: Genetic Epidemiology of CancerCancer genes and Mechanisms of Gene DisruptionGenetic VariationMutations and PolymorphismsStrategies of Gene IdentificationSegregation AnalysisLinkage AnalysisPositional CloningLimitations of Segregation and Linkage AnalysisAlternative MethodsAllele-Sharing MethodsApproches to Identify Common, Low-Risk Disease AllelesLinkage Disequilibrim and Tagging SNPsPolymorphism DatabasesEpidemiologic StudiesCase-Control StudiesCohort StudiesFamily-Based Association StudiesCase-Only DesignGene-environment Interaction and Polygenic Models of Disease RiskGenotyping Methods used in Epidemiologic StudiesWhole Genome Scans, Collaboration and ConsortiaConclusionGlossaryReferences5. Paolo Boffetta: Biomarkers in Cancer Epidemiologyand Dimitrios TrichopoulosExposure BiomarkersIntermediate BiomarkersDisease BiomarkersSusceptibility MarkesBiasBiomarker VariationTranslational StudiesConfoundingInteractionRandom ErrorPublication BiasConclusionsReferences6. Pagona Lagiou, Dimitrios Trichopoulos and Hans-Olov Adami: Concepts in Cancer Epidemiology and EtiologyEtiologyCausalityThe Scientific StudyEpidemiologyStudy DesignDescriptive StudiesEcologic StudiesAnalytic StudiesPerson-timeCohort studiesCase-control studiesGenetic epidemiology studiesThe Role of ChancerP-valueConfidence IntervalsThe Role of BiasSystematic ErrorsConfoundingBiasAnalysis of Epidemiologic StudiesEffect MeasuresInteractionMeta-analysisCausal Inference in EpidemiologyGeneral PopulationAn IARC ClassificationA Model for Causal InferenceConclusionGlossaryReferencesPART II: CANCER EPIDEMIOLOGY BY SITE-SPECIFIC CANCERS7. Paul Brennan, Lorelei Mucci and Hans-Olov Adami: Oral and Pharyngeal CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic MutationsRisk FactorsTobaccoDietAlcoholReproductive FactorsAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences8. Ellen Chang and Hans-Olov Adami: Nasopharyngeal CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilityHigh-Penetrance Gene MutationsLow-Penetrance Gene MutationsSomatic Mutations and Epigenetic ChangesRisk FactorsTobacco and Other SmokeDietHormones and Hormone ReceptorsAnthropometric MeasuresInfectionsEpstein-Barr VirusOther InfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences9. Olof Nyren and Hans-Olov Adami: Esophageal CancerClinical SynopsisDescriptive EpidemiologyGeographic and Demographic DistributionSecular Trends by Histologic TypesGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobacco and AlcoholDietReproductive Factors and HormonesAnthropometric MeasuresInfectionsOccupationMedical ConditionsOther Risk FactorsConclusionReferences10. Olof Nyren and Hans-Olov Adami: Stomach CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyFamilial OccurrenceInherited SusceptibilitySomatic EventsRisk FactorsTobaccoAlcoholTea and coffeeDietInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences11. John D. Potter and David Hunter: Colorectal CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilityOther GenesRisk FactorsTobaccoDietAlcoholReproductive FactorsPost-menopausal Hormone UseAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences12. Sherri Stuver and Dimitrios Trichopoulos: Cancer of the Liver and Biliary TracClinical SynopsisCANCER OF THE LIVERDescriptive EpidemiologyGenetic and Molecular EpidemiologyInheredited SusceptivilitySomatic EventsRisk factorsTobaccoDietAlcoholReproductive FactorsHormonesInfectionsIonizing RadiationOccupationMedical Conditions and treatmentCANCER OF THE BILIARY TRACTDescriptive EpidemiologyRisk FactorsGallbladder diseaseObesity and dietHormonal factorsMechanismsConclusionReferences13. Anders Ekbom and David Hunter: Pancreatic CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAntropometric MeasuresInfectionsPhysical activityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences14. Paolo Boffetta and Dimitrios Trichopoulos: Cancer of the Lung, Larynx, and PleuraClinical SynopsisTUMORS OF THE LUNGDescriptive EpidemiologyGenetic and Molecular EpidemiologyFamily historyRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAntropometric MeasuresInfectionsPhysical activityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsCancer of the LarynxCancer of the PleuraConclusionReferences15. Adele Green, Jolienke van der Pols and Dimitrios Trichopoulos: Skin CancerClinical SynopsisDescriptive EpidemiologyMelanomaGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAntropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsTraumaConclusionReferences16. Rulla Tamimi, Susan Hankinson, and David Hunter: Breast CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilityRisk FactorsTobaccoDietAlcoholReproductive FactorsHormones and Hormone ReceptorsAntropometric MeasuresPhysical activityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsMammographic Density and Parenchymal PatternsElectromagnetic FieldsBreast Cancer in MenConclusionReferences17. Nathalie Ylitalo, Sherri Stuver and Hans-Olov Adami: Cervical CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobaccoDietReproductive FactorsHormonesAnthropometric MeasuresSexual BehaviorInfectionsPhysical ActivityIonizing RadiationOccupationMedical ConditionsConclusionReferences18. Immaculata DeVivo, Ingemar Persson and Hans-Olov Adami: Endometrial CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilityHormone Metabolizing GenesEstrogen Metabolism and DetoxificationSteroid ReceptorsSomatic EventsRisk FactorsTobaccoDietReproductive FactorsHormonesEndogenous EstrogensExogenous HormonesAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentHypertensionOther Risk FactorsConclusionReferences19. Penelope Webb, Dorota Gertig and David Hunter: Ovarian CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilityGermline mutationsGene polymorphismsSomatic EventsRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences20. Lorelei Mucci, Lisa B. Signorello and Hans-Olov Adami: Prostate CancerClinical SynopsisDescriptive EpidemiologyIncidenceMortalityMigrant StudiesAgeGenetic and Molecular EpidemiologyInherited SusceptibilityRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentPerinatal FactorsConclusionReferencs21. Lorenzo Richiardi, Rulla Tamimi and Hans-Olov Adami: Testicular CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobaccoDietAlcoholReproductive Factors and HormonesSemen quality and fertilityAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences22. Montserrat Garcia Closas, Manolis Kogevinas and Dimitrios Trichopoulos: Urinary Bladder CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobaccoDietAlcoholReproductive Factors and HormonesAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsNontransitional cell carcinomasConclusionReferences23. Euyoung Cho, Per Lindblad and Hans-Olov Adami: Kidney CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobaccoDietAlcoholReproductive Factors and HormonesAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences24. David Savitz and Dimitrios Trichopoulos: Brain CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyRisk FactorsTobaccoDietAlcoholReproductive Factors and HormonesAnthropometric MeasuresInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsRisk Factors for Childhood Brain TumorsConclusionReferences25. Per Hall and Hans Olov-Adami: Thyroid CancerClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAnthropometric MeasuresPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentConclusionReferences26. Mads Melbye, Henrik Hjalgrim: Hodgkin's Lymphomaand Hans-Olov AdamiClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyIncidenceAge and Socioeconomic PatternsSubtypesRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAnthropometric MeasuresPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentSibship Size and Social ClassConclusionReferences27. Mads Melbye, Karin: Non-Hodgkin's LymphomasEkstrom Smedby and Dimitrios TrichopoulosClinical SynopsisDescriptive EpidemiologyIncidenceTime TrendsSubtype TrendsUnexplained IncreaseGenetic and Molecular EpidemiologyRisk FactorsTobaccoDietAlcoholReproductive FactorsHormonesAnthropometric MeasureInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferences28. Eleni Petridou, Apostolos Pourtsidis and Dimitrios Trichopoulos: LeukemiasClinical SynopsisDescriptive EpidemiologyGenetic and Molecular EpidemiologyInherited SusceptibilitySomatic EventsRisk FactorsTobaccoDietAlcoholReproductive and Perinatal FactorsHormonesAnthropometric MeasureInfectionsPhysical ActivityIonizing RadiationOccupationMedical Conditions and TreatmentOther Risk FactorsConclusionReferenceEpilogueIndex