The Adrenergic Receptors: In the 21st Century by Dianne M. PerezThe Adrenergic Receptors: In the 21st Century by Dianne M. Perez

The Adrenergic Receptors: In the 21st Century

EditorDianne M. Perez

Paperback | November 9, 2010

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An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
Title:The Adrenergic Receptors: In the 21st CenturyFormat:PaperbackDimensions:416 pages, 9.02 × 5.98 × 0 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617375594

ISBN - 13:9781617375590

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Table of Contents

Part I: Historical PerspectivesAdrenergic Receptors: Historical Perspectives From the 20th CenturyDavid B. BylundPart II: Structure-FunctionLigand Binding, Activation, and Agonist TraffickingAngela M. Finch, Valerie Sarramegna, and Robert M. GrahamNew Signal Transduction ParadigmsKenneth P. MinnemanRegulation of the Cellular Localization and Trafficking of the Adrenergic ReceptorsMichael T. Piascik, Mary Lolis García-Cazarin, and Steven R. PostAdrenergic Receptors in Clinical MedicineMartin C. Michel and Paul A. InselPart III: Imaging Adrenergic Receptors and Their FunctionUse of Fluorescent Ligands and Receptors to Visualize Adrenergic ReceptorsJohn C. McGrath and Craig J. DalyLocalization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged ReceptorsDianne M. PerezPart IV: Genetically Altered Mouse ModelsThe a1-Adrenergic Receptors: Lessons From KnockoutPaul C. SimpsonThe a2-Adrenergic Receptors: Lessons From KnockoutsChristopher M. Tan and Lee E. LimbirdThe b-Adrenergic Receptors: Lessons From KnockoutsYang Xiang and Brian KobilkaLessons From Overexpressed Mouse ModelsCinzia Perrino, Liza Barki-Harrington, and Howard A. RockmanAdrenergic Receptor Signaling Components in Gene TherapyAndrea D. Eckhart and Walter J. KochPart V: PharmacogenomicsGenetic, Molecular, and Clinical Characterization of Adrenergic Receptor PolymorphismsStephen B. LiggettMicroarray Analysis of Novel Adrenergic Receptor FunctionsBoyd Rorabaugh, June Yun, and Dianne M. PerezPart VI: Summary and Future EndeavorsSummary and Future EndeavorsDianne M. PerezIndex

Editorial Reviews

From the reviews:"...useful to anyone interested in adrenoceptor physiology/pharmacology or in the design of drugs interacting with the receptor or its signal transduction pathway." -Journal of Medicinal Chemistry"Dianne Perez has assembled a number of important contributors to the research area and grouped the 15 chapters into six parts. . many MDs, biologists, and pharmacologists will find the book . appealing, as the receptor class is involved in numerous cardiovascular and pulmonary diseases." (Boris Schmidt, ChemMedChem, Issue 1, 2006)