The Antibody Molecule: From antitoxins to therapeutic antibodies

Hardcover | November 7, 2014

byAnthony R. Rees

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The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking tounravel the most complex system in the human body outside the brain. This book charts its intriguing history, from the genetic basis of antibody diversity, through the understanding of the mechanism by which the immune system's first line of defence works, to breakthroughs in crystallography and theexploitation of immunoglobulins as therapeutic platforms to treat cancer, inflammation and allergy. Tracing the developments in immunology in chronological order, Professor Anthony R. Rees presents the historical contexts of the periods in rich detail, bringing them to life with quotes and illustrations. This fascinating book examines the literature of the time, turning points, and controversies.A must read for immunologists and life scientists, as well as historians of science and medicine.

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The Antibody Molecule follows the extraordinary journey of the medics and scientists who shaped the course of medical advances in the field of immunology. One of the oldest of the medical sciences, immunology has a history that has seen chemists, physicists and biologists alike seeking tounravel the most complex system in the human bod...

Anthony Rees is currently Principle at Rees Consulting AB, Uppsala, Sweden. He was lecturer in Molecular Biophysics and Student of Christ Church from 1980 to 1990 at the University of Oxford. From 1990-1997 he was Professor and Head of the School of Biology and Biochemistry, University of Bath where he is an Emeritus Professor and hol...

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Format:HardcoverDimensions:384 pages, 9.21 × 6.14 × 0.98 inPublished:November 7, 2014Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199646570

ISBN - 13:9780199646579

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Table of Contents

1. Antibody pre-history: The emergence of empirical immunology2. Pre-molecular immunology: The dawn of mechanism3. Structural chemistry: Locks, keys and colloids4. The foundations of antibody-antigen recognition emerge5. The cellular reformation6. The molecular path unfolds7. Uncovering the origins of antibody diversity8. Immunoglobulin constant regions9. Effector functions of constant regions10. Transmission and catabolism of IgG11. The structural context of antibody diversity12. Monoclonal antibodies and the mechanisms of hypermutation13. Antibody structure prediction and development of humanization strategies14. Antibody engineering: Improving on natural immunity15. Therapeutic antibodies: Case study 1: Prevention of respiratory syncytial virus illness16. Therapeutic antibodies: Case study 2: Targeting breast cancer17. Antibodies: The therapeutic future