The Arterial System in Hypertension by Michel Emile SafarThe Arterial System in Hypertension by Michel Emile Safar

The Arterial System in Hypertension

byMichel Emile SafarEditorM.F. O'Rourke

Paperback | November 5, 2012

Pricing and Purchase Info

$109.93 online 
$191.95 list price save 42%
Earn 550 plum® points

Prices and offers may vary in store


In stock online

Ships free on orders over $25

Not available in stores


MICHEL E. SAFAR and MICHAEL F. O'ROURKE One of the principal problems of hypertension is the precise definition of blood pressure as a cardiovascular risk factor. Clinicians indicate peak systolic pressure and end diastolic pressure in the brachial artery as the principal criteria for blood pressure measurement. Consequently, these values are as indicators for clinical management and therapeutic adjustment. This used methodology, based on indirect blood pressure measurements at the site of the brachial artery relates only to the highest and lowest pressure in that vessel, and does not give any information of the blood pressure curve itself; this carries more information than peak systolic pressure and end diastolic pressure. As a first step in better analysis of the blood pressure curve, research workers in experimental hypertension defined in addition to peak systolic pressure and end diastolic, another blood pressure value, mean arterial pressure, i. e. the average pressure throughout the cardiac cycle, and about which pressure fluctuates. This is the pressure recorded by Hales [1] and by Poiseuille [2] in their pioneering studies. By application of Poiseuille's Law, this definition of mean arterial pressure led to the concept that increased mean arterial pressure (and therefore hypertension) was related, at any given value of cardiac output, to an increase in vascular resistance, i. e. to a reduc­ tion in the caliber of the small arteries.
Title:The Arterial System in HypertensionFormat:PaperbackDimensions:240 pages, 24 × 16 × 0.07 inPublished:November 5, 2012Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9401043892

ISBN - 13:9789401043892

Look for similar items by category:


Table of Contents

Introduction; M.E. Safar, M.F. O'Rourke. 1. Mechanical Stress of the Arterial Wall and Hypertension; S. Laurent. 2. Hypertension and the Conduit and Cushioning Functions of the Arterial Tree; M.F. O'Rourke. 3. Wave Reflections and the Pathophysiology of Hypertension; R.D. Latham, D.M. Slife. 4. Structure of the Arterial System in Hypertension; C.L. Berry, J.A. Sosa-Melgarejo. 5. Cyclic Quasonine Monophosphate, Smooth Muscle Tone and Mechanical Properties of Large Arteries; M.C. Mourlon-Le Grand, B.I. Lévy. 6. Signals Regulating Arterial Contractile Function and Growth in Hypertension: Role of Angiotensin II and Nitric Oxide; J.-B. Michel, J.-F. Arnal. 7. Large Arteries and Epidemiological Aspects of Hypertension; W. McFate Smith. 8. Non-Invasive Study of the Local Mechanical Characteristics in Humans; A.P.G. Hoeks. 9. Geometry and Stiffness of the Arterial Wall in Essential Hypertension; M.E. Safar. 10. Arterial System, Left Ventricular Structure and Function; R. Gourgon, A. Cohen-Solal. 11. Autonomic Nervous System and Large Conduit Arteries: Pathophysiological and Therapeutic Aspects; G.M. London, M.E. Safar. 12. Large Arteries and Sodium in Hypertension: Pathophysiological and Therapeutic Aspects; A. Benetos, M.E. Safar. 13. Large Arteries and Calcium in Hypertension: Pathophysiological and Therapeutic Aspects; G.M. London, B.I. Lévy. 14. Wave Reflections: Clinical and Therapeutic Aspects; G.M. London, T. Yaginuma. Index.