The Behavioral Neurology of White Matter

Hardcover | May 1, 2012

byChristopher Filley

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Behavioral neurology is founded on lesions of cortical gray matter, but recently the contributions of cerebral white matter to cognitive and emotional dysfunction have also attracted attention. The Behavioral Neurology of White Matter surveys this broad and fascinating field from a clinicalperspective. Stimulated by recent improvements in neuroimaging, white matter has been carefully studied, and its role in the operations of cognition and emotion clarified by correlations with clinical observations. The relevance of normal and abnormal white matter to behavioral neurology is apparent in every context where this question has been examined: in development, aging, and in a host of diseases, intoxications, and injuries. Since the first edition of this book in 2001, steady advances have been made inunderstanding the neurobiology of white matter and its clinical significance; this edition provides a comprehensive update on this rapidly expanding field. Every chapter has been extensively rewritten, including a comprehensive revision of the account of the neuropsychiatry of white matter, aparticularly challenging area. The syndrome of white matter dementia is discussed in detail, and its refinement with new information is considered along with the proposal of mild cognitive dysfunction as a precursor syndrome in many clinical settings. In addition, two new chapters have been added, one on the emerging area of white matter changes associated with neurodegenerative disorders such Alzheimer's Disease, and another on neurologic aspects of white matter including intriguing new information on white matter plasticity. A unifying theme isthe concept of connectivity, as it is clear the white matter forms an essential component of the widespread distributed neural networks by which cognition and emotion are organized. In addition to the microconnectivity within gray matter that subserves information processing, the macroconnectivityof white matter enables information transfer - both are critical for the functions of the human mind.

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Behavioral neurology is founded on lesions of cortical gray matter, but recently the contributions of cerebral white matter to cognitive and emotional dysfunction have also attracted attention. The Behavioral Neurology of White Matter surveys this broad and fascinating field from a clinicalperspective. Stimulated by recent improvements...

Christopher M. Filley, MD is Professor of Neurology and Psychiatry, and Director of the Behavioral Neurology Section at the University of Colorado School of Medicine, and Neurology Service Chief at the Denver Veterans Affairs Medical Center. A graduate of Williams College and Johns Hopkins University School of Medicine, he completed hi...

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Format:HardcoverDimensions:400 pages, 9.25 × 6.12 × 0.98 inPublished:May 1, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199743266

ISBN - 13:9780199743261

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Table of Contents

Preface to the First EditionPreface to the Second EditionPart I The Brain, the Mind, and White Matter1. The Neurological BackgroundI. White Matter in the History of NeurologyII. The Concept of Subcortical DementiaIII. White Matter and Higher FunctionIV. The Perspective of Behavioral Neurology2. White Matter Structure and FunctionI. NeuroanatomyII. Neurophysiology3. NeuroimagingI. Computed TomographyII. Magnetic Resonance ImagingIII. Magnetic Resonance SpectroscopyIV. Magnetization Transfer ImagingV. Diffusion Tensor ImagingVI. Functional NeuroimagingVII. Mapping Neural Networks4. Development and AgingI. Development of White MatterII. White Matter Changes in Aging5. Genetic DisordersLeukodystrophiesFragile X Tremor/Ataxia SyndromeAminoaciduriasPhakomatosesMucopolysaccharidosesMuscular DystrophyCallosal Agenesis6. Demyelinative DiseasesI. Multiple SclerosisII. Neuromyelitis OpticaIII. Acute Disseminated EncephalomyelitisIV. Schilder's DiseaseV. Marburg's DiseaseVI. Bal's Concentric SclerosisVII. Tumefactive Multiple Sclerosis7. Infectious DiseasesI Human Immunodeficiency Virus InfectionII. Progressive Multifocal LeukoencephalopathyIII. Subacute Sclerosing PanencephalitisIV. Progressive Rubella PanencephalitisV. Varicella Zoster VasculopathyVI. Cytomegalovirus EncephalitisVII. Lyme Encephalopathy8. Inflammatory DiseasesI. Systemic Lupus ErythematosusII. Behet's DiseaseIII. Sj"gren's SyndromeIV. Wegener's GranulomatosisV. Temporal ArteritisVI. Polyarteritis NodosaVII. SclerodermaVIII. Primary Angiitis of the Central Nervous SystemIX. Sarcoidosis9. Toxic LeukoencephalopathyI. RadiationII. Therapeutic DrugsIII. Drugs of AbuseIV. Environmental ToxinsV. The Spectrum of Toxic Leukoencephalopathy10. Metabolic DisordersI. Cobalamin DeficiencyII. Folate DeficiencyIII. Central Pontine MyelinolysisIV. HypoxiaV. Hypertensive EncephalopathyVI. EclampsiaVII. High Altitude Cerebral Edema11. Vascular DiseasesI. Binswanger's DiseaseII. LeukoaraiosisIII. Cerebral Amyloid AngiopathyIV. CADASILV. MigraineVI. White Matter Disease of Prematurity12. Traumatic DisordersI. Traumatic Brain InjuryII. Shaken Baby SyndromeIII. Corpus CallosotomyIV. Frontal Lobotomy13. NeoplasmsI. GliomasII. Gliomatosis CerebriIII. Primary Central Nervous System LymphomaIV. Focal White Matter Tumors14. HydrocephalusI. Early HydrocephalusII. Hydrocephalus Ex VacuoIII. Normal Pressure HydrocephalusPart III White Matter and Higher Function15. Cognitive Dysfunction and DementiaI. Cognitive DysfunctionII. White Matter DementiaIII. Why Another Dementia Syndrome?16. White Matter and Neurodegenerative DiseaseI. Alzheimer's DiseaseII. Frontotemporal DementiaIII. Parkinson's DiseaseIV. Dementia with Lewy BodiesV. Huntington's DiseaseVI. Corticobasal DegenerationVII. Progressive Supranuclear Palsy17. Focal Neurobehavioral SyndromesI. AmnesiaII. AphasiaIII. AlexiaIV. Developmental DyslexiaV. Gerstmann's SyndromeVI. ApraxiaVII. AgnosiaVIII. NeglectIX. Visuospatial DysfunctionX. Akinetic MutismXI. Executive DysfunctionXII. Callosal Disconnection18. Neuropsychiatric DysfunctionI. Psychiatric Syndromes in White Matter DisordersII. Psychiatric Disorders with White Matter AbnormalitiesIII. The Relevance of White Matter to Psychiatry19. Neurologic AspectsI. Gait DisorderII. PrognosisIII. PlasticityIV. Treatment20. The Behavioral Neurology of White MatterI. White Matter-Behavior RelationshipsII. Distributed Neural NetworksIII. Neural Network DisconnectionIV. Future DirectionsV. White Matter and the Mind