The Biological Chemistry of the Elements: The Inorganic Chemistry of Life by J. J. R. Frausto da SilvaThe Biological Chemistry of the Elements: The Inorganic Chemistry of Life by J. J. R. Frausto da Silva

The Biological Chemistry of the Elements: The Inorganic Chemistry of Life

byJ. J. R. Frausto da Silva, R. J. P. Williams

Paperback | August 1, 2001

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Twenty inorganic elements, mostly metal ions, are consistently found in living systems and are essential for living systems to function correctly. The aim of this text is to discuss, describe, and explain the functional relevance of those elements: the reasons for their selection; theprocesses of their uptake, transport and final localization in cells; the regulation of these processes; and the interactive network of their reactions that connects the in vivo inorganic elements to the environment and to the genome. The first seven chapters describe the physical, chemical, and biological principles of the involvement of the elements in cellular activity, stressing how inorganic and organic chemicals react differently together in different compartments. The next twelve chapters describe the uses of theindividual essential inorganic elements and a section on the genetic control of each element is included. The final chapter discusses how the interaction of genes, proteins, small molecules, and inorganic elements plays an important role in evolution and the speciation of organisms. The second edition of 'The Biological Chemistry of The Elements' has been thoroughly revised in content and style. The main additions to the first edition concern the discussion of the links to the genome of the uptake and transfer of inorganic elements and the regulation of homeostasis, thefunctional co-operative activities of the elements, the interaction with the environment, and the evolution of usage. Recent structural and mechanistic knowledge of many biomolecules and organelles are also included. Like the higly praised first edition, this text will be the bible of bioinorganic chemistry.
J.J.R. Frausto da Silva is a Professor of Analytical Chemistry, Instituto Superior Tecnico, Universidad Tecnicia de Lisboa. R.J.P. Williams is an Emeritus Professor of Chemistry, University of Oxford.
Title:The Biological Chemistry of the Elements: The Inorganic Chemistry of LifeFormat:PaperbackDimensions:600 pages, 9.69 × 7.44 × 1.26 inPublished:August 1, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198508484

ISBN - 13:9780198508489

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Table of Contents

The chemical and physical factors controlling the elements of life1. The chemical elements in biology2. The principles of the uptake and chemical speciation of the elements in biology3. Physical separations of elements: compartments and zones in biology4. Kinetic considerations of chemical reactions, catalysis, and control5. Energy in biological systems and hydrogen biochemistry6. The role of biological macromolecules and polymers7. The functional value of the chemical elements in biological systemsThe roles of individual elements in biology8. Sodium, potassium, and chlorine: osmotic control, electrolytic equilibria, and currents9. The biological chemistry of magnesium: phosphate metabolism10. Calcium: controls and triggers11. Zinc: Lewis acid catalysis and regulation12. Non-haem iron: redox reactions and controls13. Haen iron: coupled redox reactions14. Manganese: dioxygen evolution and glycosylation15. Copper: extracytoplasmic oxidases and matrix formation16. Nickel and cobalt: remnants of early life17. Molybdenum, tungsten, vanadium, and chromium18. Phosphate, silica, and chloride: acid-base non-metals19. Sulphur, selenium, and the halogens: redox non-metals20. Integrated living systems of elements

Editorial Reviews

"This book presents a novel approach to the subject of biochemistry, which is both interesting and fascinating ... practicing scientists from either biochemistry or inorganic chemistry would find this book a valuable source for relevant information regarding the impact of the other disciplineon their own ... For a person working at the interface of inorganic chemistry and biochemistry this book will be extremely valuable. For others it will be an excellent reference to have at hand. The book is well written and understandable." Journal of Chemical Education