The Bipolar Brain: Integrating Neuroimaging and Genetics

Hardcover | June 14, 2012

EditorStephen Strakowski

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Bipolar disorder is one of the most common, and disabling, conditions affecting human kind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletelyunderstood. However, in the past decade, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this book, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify both the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. Based upon thesediscussions, the book then integrates these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians and patients as they struggle to understand this illness, as well as a guide for future investigations into thecauses of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.

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Bipolar disorder is one of the most common, and disabling, conditions affecting human kind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletelyunderstood. However, in the past decade, significant...

Dr. Strakowski was raised in a small town in northern Indiana. He developed an interest in neuroscience as an undergraduate at the University of Notre Dame, and this interest expanded to psychiatric conditions at Vanderbilt University School of Medicine. He refined his interests into bipolar disorder while training in psychiatry at McL...

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Format:HardcoverDimensions:272 pages, 11 × 8.5 × 0.98 inPublished:June 14, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199797609

ISBN - 13:9780199797608

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Table of Contents

Section I: How neuroimaging informs models of bipolar disorder.1. Caleb M. Adler and Michael Cerullo: Brain imaging techniques and their application to bipolar disorder2. Koji Matsuo, Marsal Sanches, Paolo Brambilla, and Jair C. Soares: Structural brain abnormalities in bipolar disorder3. Lori L. Altshuler and Jennifer Townsend: Functional brain imaging in bipolar disorder4. Jieun E Kim, In Kyoon Lyoo, and Perry F Renshaw: Neurochemical and metabolic imaging in bipolar disorder5. Manpreet K. Singh, Melissa P. DelBello, and Kiki D. Chang: Neuroimaging studies of bipolar disorder in youth6. Amelia Versace, Jorge R.C. Almeida, and Mary L. Phillips: Neuroimaging difference between bipolar and unipolar depression7. Heather Whalley, Jessika Sussman, and Andrew M. McIntosh: Neuroimaging in bipolar disorder and schizophreniaSection II: How genetic research informs models of bipolar disorder8. Aaron C. Vederman and Melvin G. McInnis: Genetic techniques and their application to bipolar disorder9. John I. Nurnberger, Jr.: General genetic findings in bipolar disorder10. Michael E. Talkowski, Kodavali V Chowdari, Hader Mansour, K M Prasad, Joel Wood, and Vishwajit L Nimgaonkar: Genetics of bipolar disorder and schizophrenia11. Hayley B. Clay, Satoshi Fuke, Tadafumi Kato, and Christine Konradi: Mitochondrial genetics and bipolar disorderSection III: Integration and future directions12. Roy H. Perlis and Hilary P. Blumberg: Personalized medicine - can genetics and imaging inform treatment13. Stephen M. Strakowski: Integration and consolidation - a neurophysiological model of bipolar disorder