The Cancer Degradome: Proteases and Cancer Biology

Hardcover | September 19, 2008

EditorDylan Edwards, Gunilla Hoyer-Hansen, Francesco Blasi

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This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both in vitro and in vivo; the links that have emerged between proteolysis and cell signalling; how the degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to targeting proteolysis for therapy.

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This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both in vitro and in vivo; the links that...

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Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate...

Format:HardcoverDimensions:950 pages, 9.25 × 6.1 × 0 inPublished:September 19, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387690565

ISBN - 13:9780387690568

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Table of Contents

Section 1: The Degradome and its analysisChapter 1: Protease Genomics and the Cancer DegradomeXose S. Puente, Gonzalo R Ordonez & Carlos López-OtínChapter 2: The CLIP-CHIP: A focused oligonucleotide microarray platform for transcriptone analysis for the complete human and murine cancer degradomes.Rheinhild Kappelhoff, Claire H.Wilson, & Christopher M. OverallChapter 3: The Hu/Mu ProtIn chip: A custom dual-species Oligonucleotide Microarray for profiling degradome gene expression in tumours and their microenvironmentDonald R.Scwartz, Kamiar Moin, Ekkehard Weber & Bonnie F SloaneChapter 4: Quantitative Real-Time PCR analysis of degradome gene expressionCaroline J Pennington, Robert K. Nuttall, Clara Sampieri -Ramirez, , Matthew Wallard, Simon Pilgrim & Dylan R. EdwardsChapter 5: Identification of protease substrates by mass spectrometry approaches.Mari Enoksson,Wenhong Zhu & Guy Salvesen Chapter 6: Identification of protease substrates by mass spectrometry approaches - 2.Anna Prudova, Ulrich auf dem Keller & Christopher M. OverallChapter 7: Activity based imaging and biochemical profiling tools for analysis of the cancer degradome.Vincent Dive, Margot Paulick, J.Oliver McIntyre, Lynn M. Matrisan & Matthew Bogyo.Chapter 8: Images of cleavageKamiar Moin,Mansoureh Sameni, Christopher Jedeszko, Quanwen Li, Mary B. Olive, Raymond R. Mattingly & Bonnie F. SloaneSection 2: Insights into Protease functionChapter 9: Proteolytic pathways: Intersecting cascades in cancer developmentNesrine I. Affara & Lisa M, CoussensChapter 10: Physiological functions of plasminogen activation: Effects of gene deficiences in humans and miceThomas H. Bugge Chapter 11: The plasminogen activation system in tissue remodelling and cancer invasionKasper Almholt, Anna Juncker-Jensen, Kirsty Anne Green, Helene Solberg, Leif Roge Lund & John RømerChapter 12: The urokinase plasminogen activator receptor as a target for cancer therapySilvia D'Alessio & Francesco Blasi Chapter 13: The endocytic collagen receptor uPARAP/Endo 180 in cancer invasion and tissue remodellingThore Hillig, Lars H. Engelholm & Niels BehrendtChapter 14: Physiological and pathological functions of type II transmembrane serine proteinases:Lessons from transgenic mouse models and human disease-associated mutations.Karin List & Thomas BuggeChapter 15: Analysis of cysteine cathepsin knockout mice in cancer modelsThomas Reinheckel, Vasilena Gocheva, Christoph Peters & Johanna A. JoyceChapter 16: In vitro and in vivo models of angiogenesis to dissect MMP functions.Sarah Berndt, Françoise Bruyère, Maud Jost & Agnès NoëlChapter 17: The surface transplantation model to study the tumour-host interface Maud Jost, Silvia Vosseler, Silvia Blacher, Norbert E. Fusenig, Margareta Mueller & Agnes NoelChapter 18: Unravelling the roles of proteases in cell migration in vitro and in vivoJelena Gavrilovic & Xanthe ScottChapter 19: New insights into MMP function in adipogenesisKumari L Andarawewal & Marie-Christine RiolChapter 20: TIMPs:Extracellular Modifiers in Cancer DevelopmentAditya Murty,William Cruz-Munoz & Rama KhokhaSection 3: The interface between Proteolysis and Cell SignallingChapter 21: Invadopodia: Interface for InvasionSusette C Mueller, Vira V. Artym & Thomas KellyChapter 22: uPAR and proteases in mobilization of hematopoietic stem cellsPia Ragno & Francesco BlasiChapter 23: The urokinase receptor (uPAR) and integrins constitute a cell migration signalosomeBernard DegryseChapter 24: Measuring uPAR dynamics in live cellsMoreno Zamai, Gabriele Malengo & Valeria R. CaiolfaChapter 25: Janus-faced effects of broad-spectrum and specific MMP inhibition on metastasisCharlotte Kopitz & Achim KrugerChapter 26: Cytokine Substrates: MMP regulation of inflammatory signalling moleculesJennifer H. Cox & Christopher M. OverallChapter 27: Matrix metalloproteinases as key regulators of tumour:bone interactionConor C. Lynch & Lynn M. MatrisanSection 4: The degradome as source of cancer diagnostic and prognostic markersChapter 28: The plasminogen activation system as a source of prognostic markers in cancerIb Jarle Christensen, Helle Pappot & Gunilla Hoyer-HansenChapter 29: Cysteine cathepsins and cystatins as cancer biomarkersTamara T. Lah, Natasa Obermaja, Maria Beatriz Duran Alonso & Janko KosChapter 30: Novel degradome markers in breast cancerCaroline J. Pennington, Simon Pilgrim, Paul N Span Fred C. Sweep & Dylan R. EdwardsChapter 31: Meta-analysis of gene expression microarray data: Degradome genes in healthy and cancer tissuesKristiina Iljin, Sami Kilpinen, Johanna Ivaska & Olli KallioniemiChapter 32: Degradome gene polymorphismsRoss Laxton & Shu YeChapter 33: TIMP-1 as a prognostic marker in colorectal cancerCamilla Frederiksen, Anne Fog Lomholt,Hans Jorgen Nielsen & Nils BrunnerChapter 34: Structure and inhibition of the urokinase-type plasminiogen activator receptor (uPAR)Benedikte Jacobsen, Magnus Kjaergaard, Henrik Gardsvoll & Michael PlougChapter 35: Engineered antagonists of uPA and PAI-1M. Patrizia Stoppelli, Lisbeth M, Andersen, Giuseppina Votta & Peter A. AndreasenChapter 36: MMP inhibitor clinical trials - the past present and futureBarbara FingletonChapter 37: Tailoring TIMPs for selective metalloproteinase inhibitionHideaki Nagase & Gillian MurphyChapter 38: Third Generation MMP Inhibitors: Recent advances in the development of highly selective inhibitorsAthanasios Yiotakis & Vincent DiveChapter 39: Protease activated delivery and Imaging systemsGregg FieldsChapter 40: Development of tumour selective and endoprotease-activated anticancer therapeuticsJason H. Gill & Paul M. LoadmanChapter 41: Targeting Degradome genes via engineered Viral VectorsRisto Ala-aho, Andrew H. Baker & Veli-Matti Kahari