The Cannabinoid Receptors by Patricia H. ReggioThe Cannabinoid Receptors by Patricia H. Reggio

The Cannabinoid Receptors

byPatricia H. Reggio

Paperback | December 10, 2010

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As research has progressed, the cannabinoid CB1and CB2receptors have expanded significantly in importance within the neuroscience mainstream. InThe Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part ofThe Receptors'¢ series, this volume highlights its receptor with the most thorough, focused and essential information available.

Comprehensive and cutting-edge,The Cannabinoid Receptorsserves as an ideal guidebook to what continues to be a fascinating and vital field.

Title:The Cannabinoid ReceptorsFormat:PaperbackDimensions:402 pagesPublished:December 10, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617377341

ISBN - 13:9781617377341


Table of Contents

I. Cannabinoid Receptor Ligands and Structure Activity Relationships Chapter 1. Structure Activity Relationships (SAR) of Classical Cannabinoids Raj K. Razdan Chapter 2. Endocannabinoids and Their Synthetic Analogs V. Kiran Vemuri and Alexandros Makriyannis Chapter 3. Cannabimimetic Indoles, Pyrroles and Indenes: Structure-Activity Relationships and Receptor Interactions John W. Huffman Chapter 4. Structure-Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse Agonists Yanan Zhang, Herbert H. Seltzman, Marcus Brackeen and Brian F. Thomas II. Cannabinoid Receptor Biology Chapter 5. Cannabinoid Receptor Genetics and Evolution Maurice R. Elphick and Michaela Egertová III. Cannabinoid Receptor Molecular Pharmacology Chapter 6. Cannabinoid Receptor Signal Transduction Pathways Emma Scotter, Scott Graham and Michelle Glass Chapter 7. Cannabinoid Agonist and Inverse Agonist Regulation of G-Protein Coupling Allyn C. Howlett, Lea W. Padgett and Joong-Youn Shim Chapter 8. Molecular Biology of Cannabinoid Receptors: Mutational Analyses of the CB receptors Mary E. Abood Chapter 9. Models of Cannabinoid Inverse Agonism, Neutral Antagonism and Agonism: Tools for RationalDrug Design Dow P. Hurst and Patricia H. Reggio IV. The Endocannabinoid System Chapter 10. Endocannabinoids as Modulators of Synaptic Signaling Sachin Patel and Cecilia J. Hillard Chapter 11. New Insights into the Endocannabinoid System by using Cannabinoid Receptor Knockout Mice Meliha Karsak, Itai Bab and Andreas Zimmer V. Cannabinoid Receptor Pharmacology Chapter 12. Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid Receptors Jenny L. Wiley and Billy R. Martin Chapter 13. Therapeutic Applications for Agents that Act at CB1 and CB2 Receptors Roger G. Pertwee and Adèle Thomas

Editorial Reviews

From the reviews:"The Cannabinoid Receptors arrives as the 18 member of The Receptors series and offers the reader a sophisticated overview of the structure-activity relationship advances realized in the design of cannabinoid (CB) based drugs. The book presents CB receptors in five parts . . The chapters are thoroughly referenced, including the latest primary literature, and the index serves well. . The intended audience includes industry/academic medicinal chemists and pharmacologists who are new to the CB field." (Kennerly S. Patrick, Journal of Medicinal Chemistry, September, 2009)"This book is great if you want a lot of information about the cannabinoid receptors in one place; from evolution to molecular biology and medicinal chemistry, it is all here. . This is a nicely written piece presenting molecular modelling analyses of the cannabinoid ligands. . This book is intended for newcomers to the cannabinoid field . . it is a good book to have." (David Selwood, ChemMedChem, Issue 4, 2009)