The Causes of Molecular Evolution by John H. Gillespie

The Causes of Molecular Evolution

byJohn H. Gillespie

Paperback | May 1, 1994

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This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations,the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientists must rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances havebeen made. The author's research in molecular genetics, evolution, and bio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field. The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, andmolecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in a treatment of the scientificstatus of two competing theories for the maintenance of genetic variation. Steeped in the enormous advances population genetics has made over the past 25 years, this book has proven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.

About The Author

John H. Gillespie is at University of California, Davis.
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Title:The Causes of Molecular EvolutionFormat:PaperbackDimensions:352 pages, 9.13 × 6.26 × 0.98 inPublished:May 1, 1994Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0195092716

ISBN - 13:9780195092714

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Table of Contents

1. Protein Evolution2. DNA Evolution3. The Molecular Clock4. Selection in a Fluctuating Environment5. Strong-Selection, Weak-Mutation Approximations6. Neutral Allele Theories7. Selection Theories

Editorial Reviews

"Students in molecular evolution will welcome this book....An initial attempt to introduce realistic assumptions into current models of molecular evolution and contains many stimulating and often provocative ideas." --Laurent Excoffier (University of Geneva), Human Biology