The Centromere

Paperback | June 1, 1997

byK. H. Andy Choo

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The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advance has been made on ourunderstanding of this intriguing structure, especially at the molecular level. This book brings together all available information on the centromere. It covers in details the DNA and protein components of this structure, and their individual functions, in species as diverse as budding and fissionyeasts, nematodes, Drosophila, mice, and humans; newly discovered roles of the centromere in marshalling "passenger" proteins; important emerging concepts such as latest centromeres and epigenetic factors; cytogenetic problems associated with centromere abnormalities; and practical application ofcentromere studies, such as in the construction of human artificial chromosomes for gene therapy. Supported by ample illustration, the book is written with sufficient simplicity and detail to suit both specialist and non-specialist scholars. It is the first book on the subject

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From the Publisher

The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advance has been made on ourunderstanding of this intriguing structure, especiall...

K. H. Andy Choo is at The Murdoch Institute for Research into Birth Defects, Melbourne.
Format:PaperbackDimensions:318 pages, 9.21 × 6.14 × 0.67 inPublished:June 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:019857780X

ISBN - 13:9780198577805

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Table of Contents

1. Introduction2. Centromere of budding yeast S. cerevisiae3. Centromere of fission yeast S. pombe4. Structural Organization and general properties of the higher eukaryotic centromere5. Centromere DNA of higher eukaryotes6. Centromere proteins of higher eukaryotes7. Anomalies of the human centromere8. Practical applications

Editorial Reviews

`'This book is an excellent review of recent advances in the understanding of both the structure and function of the centromer. It is clearly written with good illustrations throughout...This is a well-written and researched book about the centromere which should be in the library of anyuniversity or laboratory involved with research or teaching of cytogenetics.'Anne Kaukas, SGM Quarterly, Nov.1998