The Clinical Neurobiology of the Hippocampus: An integrative view

Hardcover | September 23, 2012

EditorThorsten Bartsch

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The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognised function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical and neurocomputational literature thatpresents basic mechanisms, theoretical models and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented in current literature, and clinical approaches and concepts arescattered throughout various clinical and basic scientific disciplines.The Clinical Neurobiology of the Hippocampus explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches.The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural and psychiatric symptoms and surpasses the ability to encode, store and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychologicaldeficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), a range of sleep conditions, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders,depression, and schizophrenia.The first part of the book covers the basic and integrative features of the hippocampus, such as the anatomy and imaging of this structure, and the basic mechanisms of hippocampal function, including the principles of hippocampus-dependent memory processing in amnesia and sleep, the mechanisms ofvulnerability and adult neurogenesis as well as the effects of stress. The second part covers the various clinical manifestations in which the hippocampus is involved and in which the preceding basic mechanisms are reflected.Bringing together a broad team of experts on the basic and clinical aspects of the hippocampus, the book provides an integrative view of the hippocampus. It is invaluable for neurologists, neuroscientists, and psychiatrists, and will stimulate interdisciplinary discussions in clinicalneuroscience.

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The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. It's recognised function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical and neurocomputational literature thatpresents basic mechanisms, theoretical models ...

Thorsten Bartsch is with the Department of Neurology, a Consultant Neurologist and Head of the Memory Disorders Group at the University Hospital of Schleswig Holstein in Kiel, Germany.

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Format:HardcoverDimensions:352 pages, 10.43 × 7.68 × 0.1 inPublished:September 23, 2012Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199592381

ISBN - 13:9780199592388

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Table of Contents

1. Thorsten Bartsch: Introduction2. Pierre Lavenex: Functional anatomy of the hippocampus3. Howard Eichenbaum: Amnesia and the hippocampal memory system4. Elias K. Michaelis: Selective vulnerability of the hippocampus5. Ron de Kloet: The influence of stress on the hippocampus6. Gerd Kempermann and Alexander Garthe: Neurogenesis in the hippocampus7. Bradford C. Dickerson: Imaging the hippocampus8. Pierre Maquet: Sleep, memory and the hippocampus9. Carol A. Barnes and Lan Hoang: The ageing hippocampus10. Alexander Prehn-Kristensen and Lioba Baving: Neurodevelopemental disorders11. Thorsten Bartsch: The hippocampus in neurological disease12. Hilkka Soininen: Alzheimer's disease13. Graeme Jackson and Radwa Badawy: Temporal lobe epilepsy, status epilepticus and mesial sclerosis14. J. Douglas Bremner: Hippocampus and post-traumatic disorders15. Glenda M. MacQueen: Depression16. Peter Falkai, Andrea Schmitt, and Oliver Gruber: Schizophrenia