The Clostridia: Molecular Biology and Pathogenesis

Other | April 1, 1997

byRood, Julian I., Julian I. Rood

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The clostridia are a group of bacteria of considerable medical and economic importance and include species responsible for generating the most potent toxins known to humans.
The Clostridia: Molecular Biology and Pathogenesis is a unique work, comprising the most complete reference on the clostridia for over 20 years, bringing together the results from some of the most innovative and exciting research in the past decade. Using a principle-oriented rather than taxonomic approach, the results from molecular biology research are placed in the context of their clinical significance, and the disease process as a whole.
This state-of-the-art work is truly comprehensive, covering and integrating the diverse topics of genetics, physiology, pathogenesis and cell biology.
Written and edited by world-renowned authorities, material is presented to give the reader an up-to-date knowledge of the pathogenic species of this important genus. Background information is followed by details of the genetics, molecular biology, biochemistry and disease mechanisms. The structure, function and mode of action of toxins and other virulence determinants is clearly presented. As such, this work will prove essential for students, teachers, research microbiologists, infectious disease clinicians, toxin specialists, and all those working in medical or veterinary bacteriology, microbial genetics and the pharmaceutical industries.

Key Features
* Covers appropriate medical and veterinary topics
* Contains authoritative contributions by international experts
* Presents the current state of knowledge and areas for future research
* Truly comprehensive--covers topics from molecular biology and physiology

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The clostridia are a group of bacteria of considerable medical and economic importance and include species responsible for generating the most potent toxins known to humans.The Clostridia: Molecular Biology and Pathogenesis is a unique work, comprising the most complete reference on the clostridia for over 20 years, bringing together t...

Richard W. Titball is the Technical Manager for Microbiology at the Defence Evaluation and Research Agency, Porton Down. He has worked on the pathogenic clostridia for the past eight years. His other research interests include the developments of vaccines against other bacterial pathogens, and he holds a number of patents in the area.

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Format:OtherDimensions:533 pages, 1 × 1 × 1 inPublished:April 1, 1997Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080542395

ISBN - 13:9780080542393

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Table of Contents

General Biology:
E. Stackebrandt and F.R. Rainey, Phylogenetic Relationships.
R.G. Labbe and N-J. Shih, Physiology of Sporulation of Clostridia.
Genome Organisation and Molecular Genetics:
E.A. Johnson, Extrachromosomal Virulence Determinants in the Clostridia.
S.T. Cole, Structure, Genetic Organization and Evolution of the Genome ofClostridium Perfringens.
J.I. Rood, Genetic Analysis inClostridium Perfringens.
D. Lyras and J.I. Rood, Transposable Genetic Elements and Antibiotic Resistance Determinants ofClostridium PerfringensandClostridiumDifficile.
Clostridia in Clinical Practice:
S.S. Arnon, Human Tetanus and Human Botulism.
S. Johnson and D.N. Gerding, Enteroxaemic Infections.
D.L. Stevens, Necrotizing Clostridial Soft Tissue Infections.
J.G. Songer, Clostridial Diseases of Animals.
Pathogenesis of Infections:
A.E. Bryant and D.L. Stevens, The Pathogenesis of Gas Gangrene.
G. Lawrence, The Pathogenesis of Enteritis Necroticans.Membrane Active Toxins and Enzymes:
R.K. Tweten, The Thiol Activated Clostridial Toxins.
R.W. Titball, Clostridial Phospholipases.
S.E.C. Leary and R.W. Titball, TheClostridium Perfringensbeta-Toxins.
J.D. Ballard and R.K. Tweten,Clostridium Septicumalpha-Toxin.Neurotoxins:
I. Henderson, T. Davis, M. Elmore, and N.P. Minton, The Genetic Basis of Toxin Production inClostridium BotulinumandClostridium Relam.
G. Schiavo and C. Montecucco, The Structure and Mode of Action of Botulinum and Tetanus Toxins.Enterotoxins:
J.F. Kokai-Kun and B.A. McClane, TheClostridium PerfringensEnterotoxin.
R.J. Carmen, S. Perelle, and M.R. Popoff, Binary Toxins fromClostridium SpiroformeandClostridium Perfringens.
J.S. Moncrief, D.M. Lyerly, and T.D. Wilkins, Molecular Biology of the Clostridium Difficile Toxins.
K. Aktories, J. Selzer, F. Hofmann and I. Just, Molecular Mechanism of Action ofClostridium DifficileToxins A and B.Other Toxins and Extracellular Enzymes:
A. Okabe and S.T. Cole, Extracellular Enzymes fromClostridium PerfringensandClostridium Histolyticumthat Damage Connective Tissue.
P. Roggentin and R. Schauer, Clostridial Sialidases.
D. Payne and P. Oysten, TheClostridium Perfringensbeta-Toxin.
Regulation of Virulence:
T. Shimizu, A. Okabe, and J.I. Rood, Regulation of Toxin Production inClostridium Perfringens.
S.B. Melville, R.E. Collie, and B.A. McClane, Regulation of Enterotoxin Production inClostridium Perfringens.
Control and Diagnosis:
J.G. Songer, Molecular and Immunological Methods for the Diagnosis of Clostridial Infections.
J.E. Brown and E.D. Williamson, Molecular Approaches to Novel Vaccines for the Control of Clostridial Toxaemias and Infections.
Index.