The Combinatorial Index

Hardcover | February 17, 1998

byBarry A. BuninEditorBarry A. Bunin

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With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest,"which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Key Features* Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods* Serves as a laboratory manual for bench chemists* Includes a chapter on linkers to assist in choice of linking strategy* Discusses strengths and limitations of the various methods* Contains a structural index showing functional group transformations in solid-phase synthesis

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From Our Editors

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers that synthetic chemists face using a combinatorial approach to medicinal chemistry problems. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and c...

From the Publisher

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provid...

From the Jacket

Combinatorial chemistry has become a major focus of research activity for pharmaceutical, agrochemical, and biotechnology companies. The explosion of combinatorial methods has created the need for a compendium of reliable synthetic transformations from the primary literature. The Combinatorial Index fills this need. Included are chapte...

Format:HardcoverDimensions:322 pages, 10 × 6.88 × 0.98 inPublished:February 17, 1998Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0121413403

ISBN - 13:9780121413408

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Table of Contents

Introduction. Background. Linkers for Solid-Phase Synthesis. Combinatorial Solid-Phase Synthesis. Analytical Methods for Solid-Phase Synthesis. The Preparation of Solution Libraries and Combined Approaches at the Solution/Solid-Phase Interface. Appendix 1: Summary of Functional Group Transformations for Combinatorial Solid-Phase Synthesis. Appendix 2: Classification of Heterocyclization Reactions. Appendix 3: Unnatural Biopolymers. Appendix 4: Oligosaccharides. Appendix 5:List of Abbreviations. Index.

From Our Editors

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers that synthetic chemists face using a combinatorial approach to medicinal chemistry problems. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations, as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled "Points of Interest," which highlights the strengths and weaknesses of various studies.

Editorial Reviews

"The Combinatorial Index provides a comprehensive collection of experimental protocols that will be of considerable practical utility to researcher working in the field of combinatorial chemistry. The organization of The Combinatorial Index provides rapid and straightforward access to classes of chemical transformation, linkers, and compound structures."--Jonathan Ellman, University of California at Berkeley"The Combinatorial Index is an indispensable reference for the solid-phase organic chemist. Both classic and modern techniques are presented in an easy-to-find format that is useful as a reference in the lab as well as a source of new ideas."--Ronald N. Zuckermann, Chiron Corporation