The Comprehensive Sourcebook Of Bacterial Protein Toxins by Joseph E. AloufThe Comprehensive Sourcebook Of Bacterial Protein Toxins by Joseph E. Alouf

The Comprehensive Sourcebook Of Bacterial Protein Toxins

byJoseph E. Alouf, Daniel Ladant, Michel R. Popoff

Hardcover | June 5, 2015

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The Comprehensive Sourcebook of Bacterial Protein Toxins 4thEdition,contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

  • Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them.
  • Focused chapters on toxin applications and common properties or general features of toxins.
Joseph E. Alouf is Professor of Microbiology at the Pasteur Institute of Lille. He is former Head of the Department of Bacteriology and Mycology at the Pasteur Institute at Paris and Chairman of its Scientific Council. He served as Secretary General of the French Society of Immunology from 1984-1986 and President of the Federation of t...
Title:The Comprehensive Sourcebook Of Bacterial Protein ToxinsFormat:HardcoverDimensions:1200 pages, 9.41 × 7.24 × 0.98 inPublished:June 5, 2015Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128001887

ISBN - 13:9780128001882


Table of Contents

  1. Evolutionary Aspects of Toxin-Producing Bacteria
  2. Mobile Genetic Elements and Pathogenicity Islands Encoding Bacterial Toxins
  3. Toxin Secretion Systems
  4. Diphtheria Toxin
  5. Pseudomonas aeruginosaToxins
  6. Bordetella Proteins Toxins
  7. Cholera Toxin,Escherichia coliThermolabile Enterotoxin and OtherVibrio choleraeEnterotoxins
  8. Vibrio parahaemolyticusVirulence Determinants
  9. Salmonella Toxin and Virulence Factors
  10. The Shiga Toxins
  11. Clostridial Neurotoxins: Cellular and Molecular Actions
  12. Clostridial Neurotoxins: Uptake and Transport
  13. Bacillus anthracisToxins
  14. ADP-Ribosylating Toxins Modifying the Actin Cytoskeleton
  15. Large Clostridial Cytotoxins Modifying Small GTpases: Structure Aspects
  16. Large Clostridial Cytotoxins Modifying Small GTpases: Cellular Aspects
  17. Pasteurella multocidaToxin
  18. Deamidating Toxins
  19. Helicobaster pyloriVacuolating Toxin
  20. Bacterial Genotoxins
  21. Basic Mechanism of Pore-Forming Toxins
  22. Membrane-Damaging and Cytotoxic Phospholipases
  23. Structure and Mode of Action of RTX Toxins
  24. Perfringolysin and Related Cholesterol-Dependent Cytolysins
  25. Staphylococcus aureusAlpha Toxin and Leucocidins
  26. Aerolysin
  27. Structural Relationships Between Small ß-Pore-forming Toxins fromClostridium perfringens
  28. Clostridium perfringensEnterotoxin
  29. Bacillus cereusEnterotoxins
  30. Bacillus Insecticidal Toxins
  31. Escherichia coliHeat-Stable Enterotoxins
  32. Superantigen Toxins
  33. Clostridial Toxins in the Pathogenesis of Gangrene
  34. Engineering of Botulinum Neurotoxins as Novel Therapeutic Tools
  35. Engineering of Bacterial Toxins for Research and Medicine
  36. Toxins as Tools in Cell Biology
  37. Inhibitors of Toxin Endocytosis
  38. Inhibitors of Pore-Forming Toxins
  39. Bacterial Toxins as Biological Weapons