The Cortical Neuron

Hardcover | August 1, 1995

EditorMichael J. Gutnick, Istvan Mody

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To understand how the cerebral cortex functions requires knowledge of single cells in this region and of their organization into cortical networks. Looking beyond the classical "wiring diagram" description of the organization of cortical cells into circuits, this innovative work focuses ondynamic aspects of cerebral cortical physiology, both at the single-neuron and network levels. Recent years have seen a remarkable expansion of knowledge about the basic cellular physiology and molecular biology of cortical neurons--their membrane properties, their synaptic characteristics, theirfunctional connectivity, their development, and the mechanisms of their response to injury. This authoritative volume includes contributions by many of the renowned neurobiologists and neurologists directly responsible for these advances. It is divided into four main sections, each of which isprefaced with an overview by a leading expert in the field. The sections cover cortical neurons and synapses, the cortical network, the developing cortical neuron, and the vulnerable cortical neuron. This final section focuses on the cortical neuron in relation to the mechanisms of epilepsy.Together, the chapters provide a balanced, up-to-date, multidisciplinary perspective on the normal and pathological function of the cells of the cerebral cortex, identifying the controversies and critical issues facing modern researchers in this exciting field.

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To understand how the cerebral cortex functions requires knowledge of single cells in this region and of their organization into cortical networks. Looking beyond the classical "wiring diagram" description of the organization of cortical cells into circuits, this innovative work focuses ondynamic aspects of cerebral cortical physiology...

Michael J. Gutnick is at Ben-Gurion University. Istvan Mody is at University of Texas.

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Format:HardcoverDimensions:424 pages, 9.61 × 6.73 × 1.18 inPublished:August 1, 1995Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:019508330X

ISBN - 13:9780195083309

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Table of Contents

Part I: General Overview1. D.A. Prince: Thirty Years Among Cortical NeuronsPart II: A Cellular and Synaptic Perspective of the Cortical Neuron2. C.F. Stevens: Cortical Synaptic Transmission: An Overview3. M.J. Gutnick and W.E. Crill: The Cortical Neuron as an Electrophysiological Unit4. H. Schulman: Signal Transduction and Protein Phosphorylation5. R.J. Dingledine and J.A. Bennett: Structure and Function of Ligand-Gated Channels6. S. Thompson, D.V. Madison and I. Mody: Synaptic Actions of Amino Acid Neurotransmitters7. R.C. Malenka: Synaptic Plasticity in Hippocampus and Neocortex: A ComparisonPart III: The Cortical Neuron as Part of a Network8. E.G. Jones: Overview: Basic Elements of the Cortical Network9. B.W. Connors and J. Amitai: Functions of Local Circuits in Neocortex: Synchrony and Laminae10. L.S. Benardo and R.K.S. Wong: Inhibition in the Cortical Network11. J.R. Huguenard, D.A. McCormic and D. Coulter: Thalamocortical Interactions12. P.C. Bush and T.J. Sejnowski: Models of Cortical NetworksPart IV: The Developing Cortical Neuron13. A.R. Kriegstein: Determination of Cellular Phenotype and the Fundamental Organization of Cortical Layering: An Overview14. J. LoTurco and A.R. Kriegstein: Neurotransmitter Signaling Befor the Birth of Neurons15. J. Noebels: Gene Control of Cortical Excitability16. R.A. Deisz and H. Luhmann: Development of Cortical Excitation and Inhibition17. P. Kellaway: Cortical Epileptogenesis in the Developing Human BrainPart V: The Vulnerable Cortical Neuron18. D.W. Choi: Glutamate Receptors and Neuronal Death: A Beginning19. J.E. Kraus and J.O. McNamara: Measurement of Cortical Neurotransmitter Receptors with Radioligand Binding: Insights into the Mechanisms of Kindling-Induced Epilepsy20. P.A. Schwartzkroin: Pathophysiology of Cortical Synapses and Circuits21. L.M. Masukawa: Pathophysiology of Cortical Areas from Human Epileptics22. G.W. Albers: Clinical Strategies for Neuronal Protection

Editorial Reviews

"Well integrated and organized and has a clarity of writing style across chapters indicative of an excellent editing effort....This excellent volume...can profit laboratory scientists as well as clinicians."--Neurological Research