The CRF Signal: Uncovering an Information Molecule

Hardcover | April 22, 2017

byJay Schulkin

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Information molecules, such as Cortico-Releasing Factor (CRF), are ancient and widely distributed across diverse organs, playing various regulatory roles. CRF has been associated with a range of human conditions, including fear and anxiety, social contact, and most recently, addiction - inparticular the euphoric feelings associated with alcohol consumption. Since its original discovery, research has unearthed that the role of this molecule is much broader than first thought. The scientific community now knows that CRF is a dynamic and diversely widespread peptide hormone that playsmany roles and has many functions, in addition to its role as a releasing factor in the brain.This book explores the role of CRF, examining the relationship between location and function. It considers recurrent features that are linked to CRF - movement and change. CRF expression in regions of the brain is tied to paying attention to novel events and invoking movement in response to thoseevents. Indeed, CRF provokes simple organized rhythmic behavior and can be mobilized under diverse conditions, including adversity. Examining the evolutionary origins of CRH, its neural functions, and its role in a variety of human characteristics and social behaviors, this book provides unique insights into CRF, and will be of interest to students and researchers in Neuroscience, Psychology, and Biology.

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Information molecules, such as Cortico-Releasing Factor (CRF), are ancient and widely distributed across diverse organs, playing various regulatory roles. CRF has been associated with a range of human conditions, including fear and anxiety, social contact, and most recently, addiction - inparticular the euphoric feelings associated wit...

Dr. Schulkin is a research Professor in the Department of Neuroscience at Georgetown University Medical Center and the Department of Obstetrics and Gynecology at the University of Washington. His work focuses on the brain and neural endocrine systems that underlie behavioral adaptation (e.g. appetitive and consummatory behaviors). He h...

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Format:HardcoverDimensions:352 pages, 9.21 × 6.14 × 0.03 inPublished:April 22, 2017Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198793693

ISBN - 13:9780198793694

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Table of Contents

1. Introduction2. Evolution and Diversification of Function of an Information Molecule: Corticotrophin Releasing Factor3. Conservation of CRF in Brains and its Regulation by Adrenal Steroids4. Radical Change: Metamorphosis and Parturition5. CRF: Contributor to Fear and Anxiety6. Social Contact, Gonadal Steroids and CRF7. Surviving, Remembering, Adversity8. Cravings and Addictions: CRF Contributor to Approach and Ingestion and Withdrawal-related Behaviors9. Conclusion: The study of CRF; An Epistemic and Medical Endeavor