The Cytokine Network and Immune Function

Hardcover | February 1, 1999

EditorJacques Theze

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The great scientific progress in our understanding of the genetics, chemistry, biology and pathophysiology of the cytokines has made clear the need for a comprehensive discussion of these molecules as part of a unified system. The Cytokine Network and Immune Functions provides just such atreatment. It represents the efforts of many of the most prominent scientists studying these molecules. Not only does it present a general discussion of each of the major cytokines or sets of cytokines; it deals in detail with how these molecules affect all aspects of immune function, and how theycontribute to a wide range of pathological conditions. As the title clearly indicates, this book does not treat individual cytokines in isolation; it recognizes that they act in a complex web of synergistic and counter-regulatory effects so as to provide opportunities for the very fine control ofimmune responses. Cytokine biology is not only a fascinating scientific discipline, giving insight into how the immune and inflammatory systems are linked and regulated, but also it is a subject of profound importance in modern medicine. As the chapters in the section of this book entitledCytokines in Pathology indicate, virtually all insults to the organism, be they acute or chronic, call upon cytokine responses and virtually every disease entity has a component involving the function of cytokines. In some diseases, such as allergy and asthma and many of the autoimmune disorders,'abnormal' cytokine responses are at the very heart of the disease process; in others, their impact may be more peripheral. There can be no doubt, however, that the study of cytokine biology has contributed greatly to the growing power of molecular medicine, transforming our approach to disease andbuilding a new armamentarium of drugs and other treatments that promise to revolutionize our capacity to control a wide range of disease states.

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The great scientific progress in our understanding of the genetics, chemistry, biology and pathophysiology of the cytokines has made clear the need for a comprehensive discussion of these molecules as part of a unified system. The Cytokine Network and Immune Functions provides just such atreatment. It represents the efforts of many of ...

Professor Jacques Theze, Immunogenetique Cellulaire, Institut Pasteur, 28 Rue du Dr. Roux, Paris, Cedex 15, France. Tel: 01 45 68 80 00. Fax: 01 43 06 98 35. Email: jtheze@pasteur.fr
Format:HardcoverPublished:February 1, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198501366

ISBN - 13:9780198501367

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Table of Contents

Part I: Overview: General Aspects of Cytokine Properties and FunctionsIntroductionProperties of cytokinesBasic cellular functions of cytokinesCytokine regulationCytokines in pathologyPart A: Cytokines and Their Receptors: Molecular Aspects1. Interleukins 2, 4, 7, 9, 13 and 152. The interleukin-6 family of cytokines and their receptors3. Interleukin 104. The tumor necrosis factor (TNF) family and related molecules5. The interleukin-1 system6. Interleukin 127. Transforming growth factor-B8. The interferons: biochemistry and biology9. Chemokines10. Cytokines and haematopoiesis11. Interleukins 16, 17 and 1812. Mechanisms of signal transduction13. Regulation of lymphokine gene expressionPart B: Cytokines and Immune Functions14. Cytokines in the development of lymphocytes15. Cytokines in the functions of dendritic cells, monocytes, macrophages and fibroblasts16. Cytokines and T-cell responses17. Regulation of humoral immunity by cytokines18. Cytokines and the cellular mechanism of inflammation19. Cytokines in the brain20. Deregulated immune responses in cytokine and cytokine receptor transgenic and knockout micePart C: Cytokines in Pathology21. Cytokines and genetic immunodeficiencies22. Cytokines in infectious diseases23. Cytokines and chemokines in acquired immunodeficiencies24. Allergic responses and cytokines25. Cytokines in organ transplantation26. Cytokines and autoimmunity27. Cytokine antagonists and autoimmunity28. Cytokines in cancer29. Immunotherapy, gene therapy, cytokines and cancer