The Cytokine Network

Paperback | February 10, 2000

EditorFran Balkwill

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Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy.They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokinereceptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can bepartially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeuticpotential in a number of chronic and acute diseases. The Cytokine Network: Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immuneresponse, and therapeutics.

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From the Publisher

Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy.They act in a complex network where one cyto...

Fran Balkwill is at Biological Therapeutics Laboratory, ICRF.
Format:PaperbackPublished:February 10, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199637024

ISBN - 13:9780199637027

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Table of Contents

PrefaceRosen et al: A Genomics Approach to Cytokine DiscoveryNelms: Cytokine Signal TransductionBrennan and Feldmann: Romagnani: Cytokine and the Th1/Th2 ParadigmMantovani and Sozzani: ChemokinesSymons and Smith: Cytokines and Cytokine Receptors Encoded by VirusesDuff: Genetic Variation in Cytokines and Relevance to Inflammation and DiseaseBalkwill: Therapeutic Manipulation of the Cytokine NetworkIndex

Editorial Reviews

'... a useful introductory text for biologists entering the complex field of cytokine research' Cell Biology International