The EGF Receptor Family: Biologic Mechanisms and Role in Cancer

Other | February 1, 2004

byCarpenter, Graham, Graham Carpenter

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The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collection of articles, each covering an aspect of teh ErbB/EGF field. This compilation features articles on growth factor ligands, neuregulins, and individual receptors. The second part of the book concentrates on the biological context of the ErbB receptors, particularly in mammary development and in cancer. It concludes with a discussion of the genetic systems that have enabled significant advances in research in this area.

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From the Publisher

The enormity of the literature on growth factors, plus the breadth of the biological disciplines and technical expertise required prohibits a comprehensive review by even a multi-disciplinary panel of authors. To provide an alternative that is feasible for authors and digestible by readers, this review compendium consists of a collecti...

Format:OtherDimensions:166 pages, 1 × 1 × 1 inPublished:February 1, 2004Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080472583

ISBN - 13:9780080472584

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Extra Content

Table of Contents

Introduction

EGF Receptor Ligands

Neuregulins: Functions, Forms, and Signaling Strategies

Epidermal Growth Factor Receptor: Mechanisms of Activation and Signaling

The Deaf and Dumb: The Biology of ErbB-2 and ErbB-3

ErbB-4: Mechanism of Action and Biology

Trafficking of the ErbB Receptors and Its Influence on Signaling

Erbbs in Mammary Development

The ErbB Receptors and their Role in Cancer Progression

Ligand-Independent Oncogenic Signaling by the Epidermal Growth Factor Receptor: V-ErbB as a Paradigm

ErbB-Targeted Therapeutic Approaches in Human Cancer

Mechanism of Action of erbB Tyrosine Kinase Inhibitors

Signaling by the Drosophila Epidermal Growth Factor Receptor Pathway during Development

The Epidermal Growth Factor System in Caenorhabaditis Elegans