The Essential Guide to N-of-1 Trials in Health by Jane NiklesThe Essential Guide to N-of-1 Trials in Health by Jane Nikles

The Essential Guide to N-of-1 Trials in Health

byJane NiklesEditorGeoffrey Mitchell

Hardcover | October 14, 2015

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N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced.

Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials.

Written and edited by some of the world's leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.

Title:The Essential Guide to N-of-1 Trials in HealthFormat:HardcoverDimensions:245 pagesPublished:October 14, 2015Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9401771995

ISBN - 13:9789401771993

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Table of Contents

Preface.- Introduction.- What are N-of-1 trials?- N-of-1 trials in the behavioural sciences.- N-of-1 trials in medical contexts.- Aggregated N-of-1 trials.- Methodological considerations for N-of-1 trials.- Randomization, allocation concealment and blinding.- Data collection and quality control.- Individual reporting of N-of-1 trials to patients and clinicians.- Assessing and reporting adverse events.- Research ethics and N-of-1 trials.- Statistical analysis of N-of-1 trials.- The economics of N-of-1 trials.- Reporting N-of-1 trials to professional audiences.- Single patient open trials.- Systematic review and meta-analysis using N-of-1 trials.- Where are N-of-1 trials headed?- Index.

Editorial Reviews

"This is a philosophical rethinking of thelimitations of randomized controlled trials and the value of cross-overexperiments conducted with a single patient. . This is a book for experiencedclinicians who are knowledgeable about current evidence-based treatmentmodalities and who can objectively recognize when to consider different optionsfor treatment." (Vincent F. Carr, Doody's Book Reviews, January 2016)