The Genetic Basis of Common Diseases

Hardcover | October 15, 2002

EditorRichard A. King, Jerome I. Rotter, Arno G. Motulsky

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Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseasesmechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer andmigraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of humangenetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of moderntherapeutics.

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Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseasesmechanisms. The second edition fully incorporates t...

Richard A. King is at University of Minnesota Medical School. Jerome I. Rotter is at University of California, Los Angeles, School of Medicine.

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Format:HardcoverDimensions:1096 pages, 8.74 × 11.26 × 1.81 inPublished:October 15, 2002Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195125827

ISBN - 13:9780195125825

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Table of Contents

Part I Approaches1. Richard A. King, Jerome I. Rotter, and Arno G. Motulsky: Approach to Common Bases of Common Diseases2. Jeffrey R. Smith, Thomas D. Gelehrter, Francis S. Collins (JS: Vanderbilt; TG: University of Michigan; FC: National Human Genome Research Institute): Molecular Genetics of Common Diseases3. Stephen S. Rich and Thomas A. Sellers (SR:Wake Forest University School of Medicine; TS: Mayo Clinic and Mayo Foundation): Genetic Epidemiologic Methods4. Jared Diamond and Jerome I. Rotter (University of California, Los Angeles, both): The Evolution of Human Genetic Diseases5. Aldons J. Lusis, David West, and Richard C. Davis (AL, DW: University of California, Los Angeles; RD: Parke-Davis Pharmaceuticals): Animal Models of Complex Genetic Disease6. Bonnie S. LeRoy and Ann P. Walker (BL: University of Minnesota; AW: University of California, Irvine): Genetic Counseling: History, Risk Assessment, Strategies, and Ethical ConsiderationsPart II Cardiopulmonary Diseases7. Arno G. Motulsky and John D. Brunzell (University of Washington, both): Genetics of COronary Atherosclerosis8. Steven C. Hunt, Paul N. Hopkins, Jean-Marc Lalouel (University of Utah, all): Hypertension9. Francine Kauffmann and Florence Demenais (INSERM, both): Chronic Obstructive Pulmonary DiseasePart III Immunologic and Infectious Diseases10. Ellen Buschman, Emil Skamene, and Erwin Schurr (EB, EmilS: McGill University Health Centre; ErwinS: Mc Gill Centre for the Study of Host Resistance): Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospects11. Deborah A. Meyers, Denise G. Wiesch, and Eugene R. Bleecker (DM, EB: Wake Forest University School of Medicine; DW: National Institute of Allergy and Infectious Disease): Genetics of Asthma and Bronchial Hyperresponsiveness12. Harry W. Schroeder, Jr. (University of Alabama at Birmingham): IgA Deficiency and Common Variable ImmunodeficiencyPart IV Gastrointestinal Disorders13. A.S. Pena (Vrije Universiteit Medical Center): Peptic Ulcer and Gastritis14. Edward J. Hollox and Dallas M. Swallow (EH: University Nottingham; Ds: University College London): Lactase Deficiiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphism15. Inflammatory Bowel Disease.Huiying Yang and Krent D. Taylor (UCLA School of Medicine, both)16. Beverly Paigen and Martin C. Carey (BP: The Jackson Laboratory; MC: Harvard Medical School): Gallstones17. Albert J. Czaja (Mayo Clinic and Mayo Foundation): Chronic Liver Disease18. Frances Busifield, G.J. Anderson, and L.W. Powell (The University of Queensland, Australia, all): Hereditary Hemochromatosis19. Susan L. Neuhausen and John J. Zone (University of Utah, both): Gluten-Sensitive EnteropathyPart V Endocrine Disorders20. Stefan K.G. Grebe (University of Outago, New Zealand): Thyroid Disease21. Steven C. Elbein, Ken C. Chui, and M. Alan Permutt: Type 1 Diabetes Mellitus22. Steven C. Elbein, Ken C. Chin, and M. Alan Permutt (SE: Univerity of Arkansas for Medical Sciencs; KC: UCLA School of Medicin; MP: Washington University School of Medicine): Type 2 Diabetes Mellitus23. George Bray and Claude Bouchard (Louisiana State University, both): Obesity24. Tatiana Foroud, Michael J. Econs, and C. Conrad Johston, Jr. (Indiana University School of Medicine, all): Genetics of Osteoporosis25. Michael A. Becker (The University of Chicago Pritzker School of Medicine): Hyperuricemia and GoutPart VI Genitourinary Disorders26. Joe Leigh Simpson (Baylor College of Medicine): Genetics of Gynecologic Disorders27. Carole Ober, Marion S. Verp, Kenneth P. Roberts, and Jon L. Pryor (CO, MS: University of Chicago; KR, JP: University of Minnesota): Genetics of Infertility and Pregnancy LossPart VII Rheumatologic Diseases28. Gerald T. Nepom and Henry A. Erlich (GN: University of Washington School of Medicine; HE: Roche Molecular Systems): Immunology and Immunogenetics29. Barbara Nepom and Richard A. King (BN: Virginia Mason Research Center, RK: University of Minnesota): Rheumatoid Arthritis30. R. Hal Scofield (University of Oklahoma): Seronegative Spondyloarthropathies31. Patrick M. Gafney, Richard A. King, and Timothy W. Behrens (University of Minnesota, all): The Genetics of Systemic Lupus Erythematosus32. John Loughlin and Kay Chapman (University of Oxford, both): Genetic Basis of Primary Osteoarthritis33. Reed E. Pyeritz (University of Pennsylvania School of Medicine): Common Disorders of Connective TissuePart VIII Cancer34. Randall W. Burt (University of Utah Health Sciences Center): Gastrointestinal Cancer35. Katherine L. Nathanson and Barbara L. Weber (University of Pennsylvania, both): Breast Cancer36. Thomas A. Sellers and Ping Yang (Mayo Clinic, both): Familial and Genetic Influences on Risk of Lung Cancer37. Maren T. Scheuner and Beth Y. Karlan (UCLA School of Medicine, both): Reproductive Organ Cancers38. Allen E. Bale, Suzanne J. Brown, and William D. Posten (Yale University School of Meidicine, all): Skin Cancer39. William B. Isaacs and Jianfeng Xu (WI: Johns Hopkins University; JX: Wake Forest University School of Medicine): Prostate Cancer40. Marshall Horwitz (University of Washington School of Medicine): Hematologic CancerPart IX Neuropsychiatric Disorders41. Magali Fernandez and Thomas D. Bird (MF: Ohio State University; TB University of Washington School of Medicine): Epilepsy42. Leena Peltonen, Janna Saarela, and Satu Kuokkanen (LP: UCLA School of Medicine; JS: University of Helsinki; SK: Columbia University): Genetic Basis of Multiple Sclerosis43. Margaret A. Pericak-Vance and Jonathan L. Haines (MP-V: Duke University Medical Center; JH: Vanderbilt University Medical Center): The Genetics of Alzheimer Disease44. Servilla D. Detera-Wadleigh and Lynn R. Goldin (SD-W: National Institute of Mental Health; LG: National Cancer Institute): Genetics of Affective Disorders45. Ann E. Pulver, Godfrey Pearlson, John McGrath, Virginia Keyes Lasseter, Karen Swarts, and George Papadimitriou (GP: Athens University Medical School: All others: Johns Hopkins University): Schizophrenia46. Dharam P. Agarwal (University of Hamburg): Alcoholism47. W. Ted Brown (SUNY Downstate Medical Center): Mental Retardation48. Rena Ellen Falk and Nathan Fischel-Ghodsian (UCLA School of Medicine, both): Hereditary Hearing Loss49. Aarno Palotie, Robert Baloh, and Maija Wessman (AP, RB: UCLA School of Medicine; MW: University of Helsinki): Genetics of MigrainePart X Other Common Problems50. Virginia P. Sybert (University of Washington School of Medicine): Common Skin Disease51. George M. Martin (University of Washington School of Medicine): Genetic Modulation of Aging and Longevity52. Douglas C. Wallace and Marie T. Lott (Emory University, both): Mitochondrial Defects in Commons Diseases53. Georgia L. Wiesner, David B. Everman, and Suzanne B. Cassidy (GW: Case Western Reserve University; DE: Greenwood Genetic Center; SC: University of California, Irvine): Constitutional Chromosome Disorders in AdultsPart XI Therapy54. John J. Mulvihill, Sarah F. Whitton, and Patrick H. Horn (University of Oklahoma College of Medicine, all): Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagensis55. Werner Kallow (University of Toronto): Pharmacogenetics, Ecogenetics, and Pharmacogenomics

Editorial Reviews

"This book will be useful for physicians with a particular interest in medical genetics, genetic counseling, and epidemiology, and it will be a helpful tool for those who wish to learn more about the genetic components of multifactoral diseases."--New England Journal of Medicine