The Genetics of Cancer: Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation

Hardcover | June 27, 1997

byGajanan V. Sherbet, M. S. LakshmiEditorGajanan V. Sherbet

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Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Key FeaturesThe contents include:* Clonal evolution of the metastasis phenotype* Cell Cycle regulation* Apoptosis in tumour growth and metastasis* Angiogenesis in cancer* Cell surface glycoproteins and their receptors* Proteinases and their inhibitors in cancer invasion* Oncogenes and cancer metastasis* Developmental genes* Tumour suppressor genes* Metastasis suppressor genes* Dominant metastasis-associated genes

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From Our Editors

Covers the current understanding of the cell cycle deregulation in tumor development. For graduates, clinicians and researchers in cancer biology.

From the Publisher

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor sup...

From the Jacket

An understanding of the genetic basis of cancer and the mechanisms governing cancer invasion and its secondary spread are fundamental to our ability to design appropriate treatments.This book, written by internationally recognised experts in cancer biology, provides insights into the deregulation of the cell cycle in tumour development...

Dr. G.V. Sherbet is DSc (Doctor of Science) London University; FRCPath (Fellow of the Royal College of Pathologists). He was a member of the scientific staff at the Chester Beatty Research Institute and University College Medical School of London, and Deputy Director of the Cancer Research Unit in the Medical School of University of Ne...

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Format:HardcoverDimensions:338 pages, 9.5 × 6.5 × 0.98 inPublished:June 27, 1997Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0126398755

ISBN - 13:9780126398755

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Extra Content

Table of Contents

Preface.
Acknowledgement.
Introduction.
Clonal Evolution of Metastasis.
Inefficiency of the Metastatic Process.
Tumor Growth and Metastatic Potential.
Cell Cycle Regulation and Metastasis.
Apoptosis in Tumor Growth and Metastasis.
Angiogenesis in Cancer.
Cell Surface Glycoproteins and Their Receptors.
Proteinases and Their Inhibitors in Cancer Invasion.
Oncogenes and Cancer Metastasis.
Developmental Genes and Their Putative Tumor Suppressor Function.
Tumor Suppressor Genes.
Metastasis Suppressor Genes.
Dominant Metastasis Associated Genes.
Epilogue.
References.

From Our Editors

Covers the current understanding of the cell cycle deregulation in tumor development. For graduates, clinicians and researchers in cancer biology.

Editorial Reviews

"Overall this book provides an excellent and often critical overview of the current state of knowledge of the genes associated with invasion and metastasis and those processes associated with it. It is a very good source of references for seminal papers and reviews, which are quite comprehensive...it will make a very useful and readable introduction to the genetics of tumor invasion and metastasis and to the concepts that underlie it."--PATHOLOGY"The book's greatest strength is in compiling and extensively referencing the massive and often paradoxical clinical literature correlating the expression patterns of cancer genes with different tumor phenotypes."--NATURE MEDICINE