The Genetics of Osteoporosis and Metabolic Bone Disease by Michael J. EconsThe Genetics of Osteoporosis and Metabolic Bone Disease by Michael J. Econs

The Genetics of Osteoporosis and Metabolic Bone Disease

EditorMichael J. Econs

Paperback | November 5, 2010

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Michael J. Econs and a distinguished team of internationally renowned experts summarize and review the latest understanding of the genetics of osteoporosis and metabolic bone disease. Topics range from an examination of the genetic contributions to osteoporosis and the many factors that must be considered when searching for genes that predispose to osteoporosis, to recent advances in the clinical and molecular biological aspects of inherited metabolic disorders. The diseases covered are both single-gene (Mendelian) traits-such as X-linked hypophosphatemic rickets-and such complex disorders as osteoporosis and Paget's disease. The book includes a discussion of current methodology for finding genes that predispose to metabolic bone diseases. Authoritative and state-of-the-art, The Genetics of Osteoporosis and Metabolic Bone Disease offers today's endocrinologists, rheumatologists, and geneticists a gold-standard compendium of current knowledge and thinking about the genetic disorders of bone and mineral metabolism, and a sound basis for powerful new genetic therapies.
Title:The Genetics of Osteoporosis and Metabolic Bone DiseaseFormat:PaperbackDimensions:473 pages, 9.02 × 5.98 × 0.07 inPublished:November 5, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617371424

ISBN - 13:9781617371424

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Table of Contents

Genetic and Environmental Determinants of Variance in Bone Size, Mass, and Volumetric Density of the Proximal Femur, Ego Seeman. How to Determine If, and by How Much, Genetic Variation Influences Osteoporosis, John L. Hopper. Vitamin D Receptor Gene Polymorphisms and Bone Mineral Homeostasis, Serge Ferrari, René Rizzoli, and Jean-Philippe Bonjour. Type 1 Collagen Polymorphisms and Osteoporosis, Stuart H. Ralston. Osteogenesis Imperfecta, Paul A. Dawson and Joan C. Marini. Vitamin D-Dependent Rickets Type I and Type II, Sachiko Kitanaka and Shigeaki Kato. Inherited Phosphate Wasting Disorders, Michael J. Econs and Kenneth E. White. X-Linked Nephrolithiasis/Dent's Disease and Mutations in the ClC-5 Chloride Channel, Steven J. Scheinman and Rajesh V. Thakker. Genetics of Tumoral Calcinosis, Kandaswamy Jayaraj and Kenneth Lyles. Fibrous Dysplasia and the McCune-Albright Syndrome, Lee S. Weinstein. The Molecular Basis for Parathyroid Hormone Resistance in Pseudohypoparathyroidism, Michael A. Levine. Fibrodysplasia Ossificans Progressiva, Eileen M. Shore, John G. Rogers, Roger Smith, Francis H. Gannon, Martin Delatycki, J. Andoni Urtizberea, James Triffitt, Martine Le Merrer, and Frederick S. Kaplan. Disorders Resulting from Inactivating or Activating Mutations in the Ca2+o-Sensing Receptor, Edward M. Brown. Multiple Endocrine Neoplasia Type 1 (MEN1), Rajesh V. Thakker. The Ret Signaling System and Its Role in Hereditary Medullary Thyroid Carcinoma, Robert F. Gagel and Gilbert Cote. Genetics of Paget's Disease of Bone, Frederick R. Singer and Robin J. Leach. Osteopetrosis, L. Lyndon Key, Jr. Hypophosphatasia, Michael P. Whyte. Jansen and Blomstrand: Two Human Chondrodysplasias Caused by PTH/PTHrP Receptor Mutations, Harald Jüppner and Caroline Silve. Genetic Linkage Analysis in Human Disease, Suzanne M. Leal and Marcy C. Speer. The Identification of Disease Genes in a Candidate Region, Fiona Francis and Tim M. Strom. Finding Mutations in Disease Genes, Peter S. N. Rowe. Index.

Editorial Reviews

"A concise, well illustrated and easy readable text. The publishers should be commended for the good quality of X-rays."-Journal of Pediatric Endocrinology and Metabolism"Written by a group of international experts, this book is of great interest to pediatricians, pediatric endocrinologists, orthopedic surgeons and geneticists. This volume describes recent advances in the molecular pathology of a series of diseases such as vitamin D receptor defects, collagen diseases, osteogenesis imperfecta, ricketts, calcinosis, fibrous dysplasia, diseases of the parathyroid, etc....A concise, well illustrated and easy readable text. The publishers should be commended for the good quality of X-rays." - Journal of Pediatric Endocrinology and Metabolism