The Golgi Apparatus: The First 100 Years

Hardcover | December 18, 2008

byJames Morré, Hilton H. Mollenhauer

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The Golgi apparatus (GA), found universally in both plant and animal cells, is typically comprised of a series of five to eight cup-shaped, membrane-covered sacs called cisternae that look something like a stack of deflated balloons. The GA is often considered the "distribution and shipping department" for the cell's chemical products. It modifies proteins and lipids (fats) and prepares them for export outside of the cell or for transport to other locations in the cell.The Golgi Apparatus traces the first 100 years of GA discovery from the first published accounts from Pavia, Italy, in 1898 to the Centenary Celebration in Pavia, Italy, in 1998 to our most recent discoveries. It summarizes the past 50 years beginning with the modern era of GA discovery initiated in 1954 and made possible by the advent of the electron microscope, methods of cell fractionation and biochemical analysis, leading up to the present era with almost exclusive focus on molecular biology. Emphasized are organization and function (especially in plants), the existence and importance of cisternal tubules, development of methods of plant and animal GA isolation and subfractionation, biochemical analyses of highly purified plant and animal GA fractions and comparison to equally highly purified reference fractions and their use in cell free systems analysis of membrane trafficking, the concept of GA function as part of an integrated system of internal endomembranes (the endomembrane system), evidence for differentiation of membranes across the stacks of GA cisternae, and flux of membrane constituents along the polarity gradient defined by membrane differentiation all culminating in the membrane maturation or flow differentiation model of GA function. More recent contributions to GA in cell growth (enlargement) and to cancer are summarized in final chapters.

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From the Publisher

The Golgi apparatus (GA), found universally in both plant and animal cells, is typically comprised of a series of five to eight cup-shaped, membrane-covered sacs called cisternae that look something like a stack of deflated balloons. The GA is often considered the "distribution and shipping department" for the cell's chemical products....

From the Jacket

The Golgi apparatus (GA) found as a ubiquitous component of all eukaryotic cells is typically comprised of stacks of 3 to 7 or more saccules called cisternae that consist of a lumen or central cavity surrounded by a membrane. At the peripheries of the saccules may be found perforations about 600 nM in diameter known as fenestrate. Such...

Format:HardcoverDimensions:320 pages, 9.25 × 6.1 × 0.27 inPublished:December 18, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387743464

ISBN - 13:9780387743462

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Table of Contents

History of the Golgi Apparatus.- Morphology of the Golgi Apparatus (Architecture/Structure).- Isolation and Subfractionation.- Golgi Apparatus Tubules.- Golgi Apparatus and Membrane Biogenesis.- Golgi Apparatus Function in the Flow-Differentiation of Membranes.- Biochemistry of the Golgi Apparatus.- Golgi Apparatus Function in Secretion.- Golgi Apparatus Replication.- Cell Free Systems for Study of Golgi Apparatus Function.- Golgi Apparatus Function in Growth and Cell Enlargement.- The Golgi Apparatus and Cancer.- The Golgi Apparatus: A Look Ahead

Editorial Reviews

From the reviews:"The volume represents a dense personal account of the activities in a very vivid field of biomedical inquiry. . it can provide an important basis for future historical analyses." (Ariane Dröscher, History and Philosophy of the Life Sciences, Vol. 34 (4), 2012)