The Heart In Rheumatic, Autoimmune And Inflammatory Diseases: Pathophysiology, Clinical Aspects And…

Hardcover | January 13, 2017

byUdi Nussinovitch

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The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and forty distinguished scientists from thirty-one countries around the globe. A review of common, as well as unusual yet clinically significant medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. Presents an up-to-date level of evidence and strengths of recommendations for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.

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The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex ...

Udi Nussinovitch, MD, PhD has mainly dedicated his research to cardiac autoimmunity and autoinflammation, cardiac manifestations of systemic diseases, cell- and gene-based cardiac therapies, and the modulation of the cardiac electrophysiologic substrate for therapeutic purposes. He has published articles in leading rheumatologic and ca...
Format:HardcoverDimensions:512 pages, 9.41 × 7.24 × 0.98 inPublished:January 13, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128032677

ISBN - 13:9780128032671

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Table of Contents

Chapter 1. Pathophysiology of Autoimmunity and Immune-Mediated Mechanisms in Cardiovascular Diseases -Shamriz O, Nussinovitch U, Rose NRChapter 2. Organ-Specific Autoimmune Myocardial Diseases: From Pathogenesis to Diagnosis and Management -Caforio ALP, Marcolongo R, Malipiero G, Agostini C, Seguso M, Gallo N, Plebani M, Iliceto S.Chapter 3. Autoantibodies Against G-Protein-Coupled Receptors in Cardiovascular Diseases: Basics and diagnostics -Bornholz B, Wallukat G, Roggenbuck D, Schimke I.Chapter 4. Immune-Mediated Accelerated Atherosclerosis -Gruber S, Tsiantoulas D, Binder CJ.Chapter 5. A Study of Cardiac Function, Atherosclerosis and Arrhythmogenicity -Nussinovitch U. Sandoo A. Malik M.

Cardiac manifestations of inflammatory arthritisChapter 6. Rheumatoid Arthritis -Dimitroulas T, Sandoo A, Skeoch S, O'Sullivan M, Yessirkepov M, Ayvazyan L, Gasparyan AY, Metsios G, Kitas GD.Chapter 7. Juvenile Idiopathic Arthritis -Ravelli A, Schiappapietra B, Verazza S, Martini A.Chapter 8. Spondyloarthritides: ankylosing spondylitis, psoriatic arthritis and reactive arthritis -Braun J, Heslinga SC, Trappe HJ, Nurmohamed MT.Chapter 9. Polymyalgia Rheumatica -Bartoloni E, Pucci G, Alunno A, Gerli R, Schillaci G.

Cardiac involvement in autoimmune and connective tissue diseasesChapter 10. Systemic Lupus Erythematosus -Tselios K, Urowitz MB.Chapter 11. Neonatal Lupus -Miliaresis C, Phoon C, Buyon J, Friedman D.Chapter 12. Sjögren's Syndrome -Fragkioudaki S, Moutsopoulos HM, Mavragani CP.Chapter 13. Systemic Sclerosis -Vacca A.Chapter 14. Dermatomyositis and Polymyositis -Diederichsen LP, Sanner H, Sjaastad I, Lundberg IE.

Cardiac manifestations crystal-induced arthritisChapter 15. Gout -van Durme C, Landewé R.

Cardiac manifestations of large vessel vasculitidesChapter 16. Giant Cell Arteritis -Koster MJ, Matteson EL, Warrington KJ.Chapter 17. Takayasu's Arteritis -Zhang H, Yang L, Jiang X.

Cardiac manifestations of medium vessel vasculitidesChapter 18. Polyarteritis Nodosa -Guillevin L.Chapter 19. Kawasaki Disease -Reutera C, Mithala L, Shulman S.

Cardiac manifestations of small vessel vasculitisChapter 20. ANCA-Associated Vasculitis: Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome) and Granulomatosis With Polyangiitis (Wegener's Granulomatosis) -Hazebroek MR, van Paassen P, Dennert R, Heymans S.

Cardiac manifestations of variable vessel vasculitisChapter 21. Behçet's Disease -Soriano A, Pipitone N, Salvarani C.

Post-infectious autoimmune cardiac diseasesChapter 22. Rheumatic Fever and Rheumatic Heart Disease -Guilherme L, Sampaio RO, Freschi de Barros S, Köhler KF, Spina GS, Tarasoutchi F.Chapter 23. Chagas Cardiomyopathy -Fernandes F, Moreira CHV, Barbosa-Ferreira JM, Sabino EC.

AutoinflammationChapter 24. Familial Mediterranean Fever -Nussinovitch U, Livneh A.

Therapeutic approaches: mechanisms of action and cardiac effectsChapter 25. Desirable and adverse effect of anti-inflammatory agents on the heart -Imazio M, Maestroni S, Valenti A, Ramoni V, Brucato A.Chapter 26. The effects of immunosuppressive and cytotoxic drugs on the heart -Russell SD.Chapter 27. Autoantibody-Directed Therapy in Cardiovascular Diseases -Müller J, Wallukat G, Schimke I.Chapter 28. Cardiac Immunomodulation -Könemann S, Dörr M, Felix SB.