The History of a Genetic Disease: Duchenne Muscular Dystrophy or Meryons Disease

Hardcover | March 24, 2011

byAlan E. H. Emery, Marcia L. H. Emery

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Duchenne Muscular Dystrophy is a disease that only affects males, with an incidence of around 1 in 3500 new-born baby boys. Its relentless progress is characterized by loss of the ability to walk around the age of 10 or 11, leading to a wheelchair life, and death from cardiac and respiratoryproblems usually around the late teens or early twenties.Edward Meryon was the first person to give a full and detailed clinical description of what later researchers know as Duchenne Muscular Dystrophy. His research identified many facets of the condition which we now take for granted, for example that it only affects males, that it is an inheritedcondition carried in female genes, that it is a disease of the muscle system, and its causes. Until recently, Meryon has not been given credit for his contribution to the subject. In this book, the history of Duchenne Muscular Dystrophy is traced in detail, and is interwoven with a commentary ofMeryon's research which has led to our current understanding of the disease, will full references and informative, historically relevant illustrations.This book concludes with a summary of the current position regarding diagnosis, prevention through counselling and prenatal diagnosis, and new encouraging approaches to treatment through molecular genetics.

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Duchenne Muscular Dystrophy is a disease that only affects males, with an incidence of around 1 in 3500 new-born baby boys. Its relentless progress is characterized by loss of the ability to walk around the age of 10 or 11, leading to a wheelchair life, and death from cardiac and respiratoryproblems usually around the late teens or ear...

Over a long career Alan E. H. Emery has published some 400 articles and written or edited 24 books, mainly, but not exclusively, concerned with genetics and neuromuscular disorders. In 1989 he helped found the European Neuromuscular Centre and was its first Research Director and later in 2001 established the Section of Medical Genetic...

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Format:HardcoverDimensions:256 pages, 9.21 × 6.14 × 0.1 inPublished:March 24, 2011Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199591474

ISBN - 13:9780199591473

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Table of Contents

Preface1. The history of Muscular Dystrophy: a unique story2. Early history of Muscular Dystrophy3. Edward Meryon's contribution to Muscular Dystrophy4. The life of Edward Meryon (1807-1880)5. Duchenne de Boulogne (1806-1875)6. Refining the clinical picture7. Resolution of heterogeneity8. Nosology of the Dystrophies9. Recognition of other types of Muscular Dystrophy10. Biochemical diagnosis and carrier detection11. Pathogenesis of Duchenne dystrophy12. The search for the gene13. Current trends and the future