The HLA FactsBook

Other | December 1, 1999

byMarsh, Steven G.E., Steven G.e. Marsh

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TheHLA FactsBookpresents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity.

Key Features
* Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists
* Up-to-date, complete listing of HLA alleles
* Invaluable reference resource for immunologists, geneticists, and cell biologists
* Combines both structural and functional information, which has never been compiled in a single reference book previously
* Serological specificity of allotypes
* Identity of material sequenced including ethnic origin
* Database accession numbers
* Population distribution
* Peptide binding specificities
* T cell epitopes
* Amino acid sequences of allotypes
* Key references

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From the Publisher

TheHLA FactsBookpresents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual e...

Linda Barber's doctoral and post-doctoral studies examined the structure and function of MHC classI and classII molecules with emphasis on the impact of polymorphism on peptides bound and presented for immune surveillance. Dr. Barber's current interests focus on utilizing our understanding of the role of MHC molecules in T cell and NK ...

other books by Marsh, Steven G.E.

The Hla Factsbook
The Hla Factsbook

Paperback|Dec 22 1999

$136.97 online$143.95list price
Format:OtherDimensions:416 pages, 1 × 1 × 1 inPublished:December 1, 1999Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080542506

ISBN - 13:9780080542508

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Extra Content

Table of Contents

Preface.
Abbreviations.
The Introductory Chapters:
Introduction.
Human Leukocyte Antigens (HLA) Determine Histocompatibility in Transplantation.
The Organisation of HLA Genes Within the HLA Complex.
HLA Class I Antigens and Alleles: Workshops and Nomenclature.
HLA Class II Antigens and Alleles: Workshops and Nomenclature.
HLA Typing at the DNA Level.
HLA Class I and II Molecules Present Peptide Antigens to Different Types of T Cell.
HLA Class I Molecules Control Natural Killer Cell Function.
Three-Dimensional Structures of HLA Class I Molecules.
Three-Dimensional Structures of HLA Class II Molecules.
HLA Polymorphism, Peptide Binding Motifs and T-Cell Epitopes.
Evolution and Anthropology of HLA.
HLA and Disease.
Alloreactions in Transplantation.
The HLA Class I and Class II Loci.