The Hla Factsbook

Paperback | December 22, 1999

bySteven G.e. Marsh, Peter Parham, Linda D. Barber

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The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes HLA-A, B, C, DP, DQ, and DR that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Key Features* Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists* Up-to-date, complete listing of HLA alleles* Invaluable reference resource for immunologists, geneticists, and cell biologists* Combines both structural and functional information, which has never been compiled in a single reference book previously* Serological specificity of allotypes* Identity of material sequenced including ethnic origin* Database accession numbers* Population distribution* Peptide binding specificities* T cell epitopes* Amino acid sequences of allotypes* Key references

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From the Publisher

The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes HLA-A, B, C, DP, DQ, and DR that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual e...

From the Jacket

How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, and structure? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?The Academic Press FactsBook series has established itself as t...

Dr. Parham was born in London and read natural sciences at Cambridge University. He began study of the genetic basis of HLA polymorphism in 1973 and has continued this line of research ever since. Dr. Parham is currently Professor of structural biology and microbiology and immunology at Stanfor University.Linda Barber's doctoral and po...
Format:PaperbackDimensions:398 pages, 9 × 6 × 0.68 inPublished:December 22, 1999Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0125450257

ISBN - 13:9780125450256

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Extra Content

Table of Contents

Preface.
Abbreviations.
The Introductory Chapters:
Introduction.
Human Leukocyte Antigens (HLA) Determine Histocompatibility in Transplantation.
The Organisation of HLA Genes Within the HLA Complex.
HLA Class I Antigens and Alleles: Workshops and Nomenclature.
HLA Class II Antigens and Alleles: Workshops and Nomenclature.
HLA Typing at the DNA Level.
HLA Class I and II Molecules Present Peptide Antigens to Different Types of T Cell.
HLA Class I Molecules Control Natural Killer Cell Function.
Three-Dimensional Structures of HLA Class I Molecules.
Three-Dimensional Structures of HLA Class II Molecules.
HLA Polymorphism, Peptide Binding Motifs and T-Cell Epitopes.
Evolution and Anthropology of HLA.
HLA and Disease.
Alloreactions in Transplantation.
The HLA Class I and Class II Loci .

Editorial Reviews

"One might consider this book to be an HLA Thesaurus, which should be on the desk of every serious HLA research. The compilers have done a excellent job."-European Federation for Immunogenetics Newsletter "This information will prove invaluable to each laboratory and I suggest that each should have a copy of this book...the authors deserve our thanks for bringing the present available information together in one text - to do this was no mean feat."-British Society of Histocompatibility and Immunogenetics Newsletter"...the data are an absolute treasure...I must have spent days looking for this kind of information in the past."-Immunology Today