The Impact of Stereochemistry on Drug Development and Use by Hassan Y. Aboul-eneinThe Impact of Stereochemistry on Drug Development and Use by Hassan Y. Aboul-enein

The Impact of Stereochemistry on Drug Development and Use

byHassan Y. Aboul-enein, Irving W. Wainer

Hardcover | April 11, 1997

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Provides an authoritative source of practical information on stereochemistry and its impact on drug development. Unlike other books which focus on synthesis, this work explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmaceutical industry today. It specifically addresses how the body metabolizes chiral molecules; the varying effects of different chiral molecules; and provides detailed evaluations of current seperation techniques. Includes regulatory information.
About the editors Hassan Y. Aboul-Enein holds a PhD in pharmaceutical and medicinal chemistry from the University of Mississippi. He is currently involved in biomedical and pharmaceutical research at King Faisal Specialist Hospital & Research Centre in Riyadh, Saudi Arabia. He is a member of the editorial boards of several journals, i...
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Title:The Impact of Stereochemistry on Drug Development and UseFormat:HardcoverDimensions:728 pages, 9.3 × 6.35 × 1.55 inPublished:April 11, 1997Publisher:Wiley

The following ISBNs are associated with this title:

ISBN - 10:0471596442

ISBN - 13:9780471596448

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Table of Contents

Partial table of contents:

Chirality and Drug Hazards (H. Aboul-Enein & L. Basha).

Stereochemical Aspects of Drug Metabolism (J. Mason & A. Hutt).

Some Examples for Stereoselective Biotransformation of Drugs (G. Blaschke).

Chiral Barbiturates: Synthesis, Chromatographic Resolutions, and Biological Activity (J. Bojarski).

Stereogenic Elements of Pharmaceutical Compounds: Some Aspects on Isomerism, Resolution, and Stereochemical Integrity (S. Allenmark).

The Importance of Chiral Separations in Pharmaceuticals (S. Ahuja).

Micelle-Mediated Capillary Electrophoretic Separation of Enantiomeric Compounds (M. Swartz & P. Brown).

Chiral Derivatization Reagents in the Bioanalysis of Optically Active Drugs with Chromophore-Based Detection (R. Büschges, et al.).

Circular Dichroism in the Study of Stereoselective Binding of Drugs to Serum Proteins (C. Bertucci, et al.).

From Our Editors

This book is an authoritative source of information on stereochemistry and its impact on drug development. It explores the physiological impact of chiral molecules -- molecules that can be found in "right-handed" and "left-handed" forms. It addresses how the body metabolizes chiral molecules, examines the varying effects of different chiral molecules and provides detailed evaluations of separation techniques.Emphasizes physiological effects.-- Includes the latest regulatory issues and guidelines (US and international).