The Kinetochore:: From Molecular Discoveries to Cancer Therapy

Hardcover | November 11, 2008

EditorPeter De Wulf

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Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.

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Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries ...

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Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries ...

Format:HardcoverDimensions:524 pages, 9.25 × 6.1 × 0.04 inPublished:November 11, 2008Publisher:Springer New YorkLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0387690735

ISBN - 13:9780387690735

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Table of Contents

Foreword.- The kinetochore and centromere: a historical perspective.- The mitotic and meiotic chromosome cycles in eukaryotes.- The centromere and neocentromere.- Human artificial centromeres.- Architectural and functional organization of kinetochores.- Holokinetochores.- Evolution of centromeres and kinetochores.- Structural and functional analysis of the spindle.- Kinetochore-spindle attachment.- Regulation of kinetochore activity.- Epigenetic regulation of kinetochore activity.- Regulation of spindle assembly checkpoint activity at the kinetochore.- Role of the kinetochore in meiosis.- The kinetochore cancer connection.- Kinetochore mutations in cancer tissues.- The kinetochore as an anti-cancer target.