The Legacy of Cell Fusion

Hardcover | April 1, 1981

EditorSiamon Gordon

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The powerful method of viral-induced fusion of animal cells was invented by Henry Harris and his colleagues in 1965, in order to study the genetics of somatic animal cells. This volume evaluates the impact of cell hybridisation on the study of cell differentiation, gene mapping, generegulation, and the development of monoclonal antibodies. Studies are presented on nuclear structure and function, intracellular transport, membrane protein mobility, and nuclear-cytoplasmic interaction in heterokaryons and other cells. Early experiments by Harris and co-workers suggested that geneloss plays an important role in tumour formation and that the malignant phenotype could be suppressed by hybridisation with non-malignant cells. This principle has since been shown to apply to a wide range of natural and experimental tumours, in species ranging from Drosophila to man.Tumour-suppressor genes are discussed, together with the role of radiation-hybrid mapping in the analysis of genetic tumours. The book concludes with an article in which Henry Harris examines unsolved questions that remain to be studied in the link between cell growth and differentiation.

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From the Publisher

The powerful method of viral-induced fusion of animal cells was invented by Henry Harris and his colleagues in 1965, in order to study the genetics of somatic animal cells. This volume evaluates the impact of cell hybridisation on the study of cell differentiation, gene mapping, generegulation, and the development of monoclonal antibo...

Siamon Gordon, Glaxo Professor of Cellular Immunology, Sir William Dunn School of Pathology, Oxford.
Format:HardcoverDimensions:318 pages, 9.21 × 6.14 × 0.01 inPublished:April 1, 1981Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198547722

ISBN - 13:9780198547723

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Table of Contents

1. Heterokaryons reveal that differentiation requires continuous regulation2. The instability of differentiation in hepatomas3. Nuclear protein sorting in heterokaryons and homokaryons4. Some insights into the replication of damaged DNA in mammalian cells5. The role of the nucleolus in the transfer of information from nucleus to cytoplasm6. Transcription by immobile RNA polymerases7. Lateral mobility of membrane proteins - a journey from heterokaryons to laser tweezers8. Intracellular transport of secretory proteins within intact transient heterokaryons and homokaryons9. Radiation hybrid mapping: an idea whose time has finally arrived10. The cloning of tumour suppressor genes11. The road to monoclonal antibodies12. The genetic analysis of human cancer13. Genes in control of cell proliferation and tumorigenesis in Drosophila14. Genetics and molecular biology of tumour formation in Xiphophorus15. Loss of function mutations in human cancer16. Cancer suppression by the retinoblastoma gene17. The p53 pathway: past and future18. Somatic cell genetics and the search for colon cancer genes19. Roles of the myc gene in cell proliferation and differentiation, as deduced from its role in tumorigenesis20. Genes that suppress the action of mutated ras genes21. Unfinished business

Editorial Reviews

`Plan to enjoy this book.'Paul L. McNeil, College of Georgia, Trends in Cell Biology, Vol. 5, June 1995