The Microbial Models of Molecular Biology: From Genes to Genomes

Hardcover | March 10, 2004

byRowland H. Davis

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This book explains the role of simple biological model systems in the growth of molecular biology. Essentially the whole history of molecular biology is presented here, tracing the work in bacteriophages in E. coli, the role of other prokaryotic systems, and also the protozoan and algal models- Paramecium and Chlamydomonas, primarily - and the move into eukaryotes with the fungal systems - Neurospora, Aspergillus and yeast. Each model was selected for its appropriateness for asking a given class of questions, and each spawned its own community of investigators. Some individuals made thetransition to a new model over time, and remnant communities of investigators continue to pursue questions in all these models, as the cutting edge of molecular biological research flowed onward from model to model, and onward into higher organisms and, ultimately, mouse and man.

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This book explains the role of simple biological model systems in the growth of molecular biology. Essentially the whole history of molecular biology is presented here, tracing the work in bacteriophages in E. coli, the role of other prokaryotic systems, and also the protozoan and algal models- Paramecium and Chlamydomonas, primarily -...

Rowland H. Davis is at University of California, Irvine.

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Format:HardcoverDimensions:352 pages, 6.1 × 9.29 × 1.1 inPublished:March 10, 2004Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195154363

ISBN - 13:9780195154368

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Table of Contents

1. Model systems, model organisms2. Morgan's progeny3. Neurospora4. Aspergillus5. Yeast6. Leaving the fungi7. Escherichia coli8. The T bacteriophages9. Temperate phage and transduction10. DNA11. Prokaryotes take center stage12. Prokaryotes: Later contributions13. Cytoplasmic inheritance: The ciliates14. Organelle genetics: Yeast and Chlamydomonas15. Yeast becomes a supermodel16. The Filamentous fungi: Eclipse and renewal17. The role of biochemistry18. Genomics19. The age of model organismsAppendix 1. Life cycles and genetic principlesAppendix 2. Macromolecules and the Central DogmaAppendix 3. Genetic engineeringNotesReferencesName indexSubject index

Editorial Reviews

"The strong point of this book is the richness and precision of the scientific information provided. Particularly for the period extending from the 1930's to the 1960's... Any historian of science intending to study an episode touched on in this book should in the future consult this bookfirst to obtain precise and sure scientific background for his or her study." Journal of the History of Biology