The Molecular and Supramolecular Chemistry of Carbohydrates: Chemical Introduction to the Glycosciences by Serge DavidThe Molecular and Supramolecular Chemistry of Carbohydrates: Chemical Introduction to the Glycosciences by Serge David

The Molecular and Supramolecular Chemistry of Carbohydrates: Chemical Introduction to the…

bySerge DavidTranslated byRosemary Green Beau

Paperback | September 1, 1997

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There is currently a great deal of interest in carbohydrate research among chemists and biologists, in both academic and industrial laboratories. One reason is the involvement of oligosaccharide molecules in many recognition phenomena in the living world. Another reason is the growing demandfor chiral synthesissugars are an amazingly cheap source of chirality but must be efficiently processed. Thirdly the role of conformation in carbohydrate interactions has stimulated much experimental and theoretical work. There are causal links between advances in each of these fields, frommolecular orbitals to immunochemistry, so that no research worker in his narrow specialisation can afford to ignore what is going on elsewhere. Thus a body of knowledge has been built from what is now called the 'glycosciences'. This book attempts to describe glycosciences in their true perspective.Organic chemistry is the backbone of the presentation, but carbohydrate chemistry offers a wealth of supramolecular associations. This book is unique, among similar texts on carbohydrates, in that half its content is devoted to the description of important examples of such interactions. Theopening chapters deal with the problems of configuration, conformation, derivatization, and modifications of monosaccharides, with examples on their utilization in total synthesis. The anomeric effectthe most popular of all stereoelectronic effects, and a gift to carbohydrate chemists and chemistsin generalis discussed at length. The following chapters deal with oligosaccharides; the essentials of enzymic synthesis, with its high performances; and the sialic acids, which are at the forefront of carbohydrate research. The author describes recognition reactions, including blood groupphenomena, interactions involving sialic acids, the active site of heparin, tumour markers, and selectins. The association of sugars with small molecules, notably with inorganic species, is the subject of another chapter. Throughout the book, great attention has been given to practical detailsespecially in the description of experiments involving unfamiliar techniques. Many tables, figures, diagrams, experimental protocols and a survey of the literature up to March 1996 will help the reader to understand the salient facts and visualize a broad spectrum of ideas.
Serge David is at University of Paris-Sud.
Title:The Molecular and Supramolecular Chemistry of Carbohydrates: Chemical Introduction to the…Format:PaperbackDimensions:330 pages, 9.21 × 6.14 × 0.71 inPublished:September 1, 1997Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0198500467

ISBN - 13:9780198500469

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Table of Contents

1. Configuration of monosaccharides2. Conformation of monosaccharides and their derivatives3. Alkyl and aryl glycosides and glycosamines4. Nomenclature5. Reactions of hydroxyl groups6. Reactions of carbonyl groups and hemiacetals7. Changes of configuration, unsaturated and branched-chain sugars8. Sugars in chiral synthesis9. Oligosaccharides : configuration and analysis10. Chemical transformations and synthesis of oligosaccharides11. Associations with anions, cations, and inorganic molecules12. Sialic and sialylated oligosaccharides13. Glycoconjugates14. Structure of some crystallized sugar-protein complexes15. Antigens and antibodies. Lectins16. ABH and related blood group antigens17. Important recognition events involving oligosaccharides in the living world18. Oligosaccharides as ligands to DNA

Editorial Reviews

`This translation from the French will be of interest to both academic and industrial organic chemists working with oligosaccharides ... contains a great deal of useful data.'Aslib Book Guide, vol. 63, no. 3, March 1998