The Motoneurone And Its Muscle Fibres

Hardcover | August 17, 2006

byDaniel Kernell

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The Motoneurone and its Muscle Fibres presents a state-of-the-art summary of knowledge concerning the motoneurones, vital for innervating and commanding skeletal muscles. No muscle action would be possible without motoneurones. These cells are therefore absolutely essential for the executionof normal behaviour and for life support. It is their degeneration that leads to various kinds of motoneurone disease (e.g. ALS) that are often ultimately lethal. However, the study of motoneurones is also important for general insights as to how neurones work, because the motoneurone is probablythe best understood kind of nerve cell so far in neuroscience. Motoneurones of the spinal cord were the first type of central nerve cell to be subjected to detailed physiological measurements, and much is known about how their activity is regulated by synapses from other central neurones. For mostof the individual neurones within the central nervous system, the precise functional tasks are difficult to define. However, for motoneurones much is now known about their short- and long-term interactions with their main targets, the skeletal muscle fibres. Functions of neurones must be analyzed inrelation to the response properties of their target cells. Therefore, this book deals with both, summarizing classical as well as recent knowledge concerning the motoneurone and its muscle fibres. This is the first time that so many aspects of this broad subject matter are treated in onecomprehensive monograph.

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The Motoneurone and its Muscle Fibres presents a state-of-the-art summary of knowledge concerning the motoneurones, vital for innervating and commanding skeletal muscles. No muscle action would be possible without motoneurones. These cells are therefore absolutely essential for the executionof normal behaviour and for life support. It ...

Daniel Kernell grew up in Stockholm and studied medicine at the Karolinska Institutet. From 1961-1972 he was associated with the Nobel Institute for Neurophysiology (Karolinska Institutet). After being awarded his PhD in 1965, he spent his postdoctoral period in Oxford (UK) 1966-1967. He moved to the Netherlands in 1972, where he work...

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Format:HardcoverDimensions:360 pages, 9.69 × 6.73 × 0.87 inPublished:August 17, 2006Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198526555

ISBN - 13:9780198526551

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Table of Contents

1. Why bother about motoneurones?2. Basic neuromuscular properties3. Muscle unit properties and specializations4. Neuromuscular transmission5. Motoneurones: morphology, cytology and topographical organization6. Motoneurones: electrophysiology7. Motoneurones: synaptic control8. Motoneurone populations and the gradation of muscle force9. Short-term plasticity: fatigue and potentiation10. Denervation and reinnervation11. Long-term plasticity12. Genetic specification and lifespan development